Xinru Xiao

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The authors describe a modified anterior transpetrous approach (ATPA) for the surgical resection of 21 cases of petroclival meningiomas (PCMs). Briefly, a curved periauricular skin incision was used. The cerebellar tentorium and the dura on the petrous apex were coagulated and incised to expose the petrous apex bone fully. The drilling of the petrous apex(More)
The authors describe a two-bone-flap craniotomy technique to avoid the bone defect caused by the transpetrosal–presigmoid approach. Briefly, this technique includes three steps. The first step is to elevate a temporoparietal bone flap located superiorly to the transverse and sigmoid sinuses. The second step is to dissect the transverse and sigmoid sinuses(More)
BACKGROUND Although there has been great development in the anatomical understanding and operative techniques for skull base tumors, controversy still exists regarding the optimal surgical strategies for the FMMs. We report clinical and radiologic features as well as the surgical findings and outcome for patients with FMM treated at our institution over the(More)
OBJECTIVE Resection of thalamic cavernous malformations (CMs) is controversial. The goals of this study were to evaluate the outcome of thalamic CMs after surgical resection, assess predictors of prognosis, and review the literature. METHODS The authors used the modified Rankin scale (mRS) to retrospectively evaluate the presentation, surgery, and(More)
SET and MYND domain-containing protein 3 (SMYD3) is a histone H3 lysine 4 (H3K4) di- and tri-methyltransferase that forms a transcriptional complex with RNA polymerase II and plays an important role in early embryonic lineage commitment through the activation of lineage-specific genes. SMYD3 activates the transcription of oncogenes and cell cycle genes in(More)
Chondromas and chondrosarcomas of the cranial base are rare neoplastic diseases. The aim of the present study was to evaluate the diagnosis and microsurgical treatment of these difficult cranial base tumors. A total of 19 patients who underwent microsurgery were pathologically diagnosed with cranial base chondromas or chondrosarcomas and their clinical data(More)
OBJECTIVE To investigate the influence of body temperature on the outcome of head injuries. METHODS The data of body temperature and outcomes of patients with head injuries admitted to Tiantan Hospital between July 1997 and July 1999 was analyzed retrospectively. The admission temperature was divided into 4 groups: hypo-temperature (with body temperature(More)
Mutations in the RNaseH2A gene are involved in Aicardi‑Goutieres syndrome, an autosomal recessive neurological dysfunction; however, studies assessing RNaseH2A in relation to glioma are scarce. This study aimed to assess the role of RNaseH2A in glioma and to unveil the underlying mechanisms. RNaseH2A was silenced in glioblastoma cell lines U87 and U251.(More)
BACKGROUND Skull base chordomas are challenging and have a high rate of recurrence. METHODS A modified anterior transpetrous approach (ATPA) was performed in 17 upper clivus chordomas, and clinical data were retrospectively studied. RESULTS All 17 cases were radically treated via the modified ATPA, and the total removal and subtotal removal rates were(More)
Objective: To investigate the clinical characteristics and causes of the patients who received an emergency reoperation involving a craniotomy after neurosurgery for skull base tumors. Materials and methods: A retrospective analysis was performed with 14 patients who underwent an emergency reoperation involving a craniotomy after received skull base surgery(More)