Xinmin Zhao

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Acknowledgment First and foremost, I would like to express my deepest gratitude to my advisor, Dr. Norman I. Badler, for his invaluable guidance and advice, for his confidence in me from the beginning to the end, for all the freedom to pursue the research topics that interest me the most, and for the excellent research environment that he fosters at the(More)
BACKGROUND YN968D1 (Apatinib) selectively inhibits phosphorylation of VEGFR-2 and tumor angiogenesis in mice model. The study was conducted to determine the maximum tolerated dose (MTD), safety profile, pharmacokinetic variables, and antitumor activity in advanced solid malignancies. METHODS This dose-escalation study was conducted according to the(More)
Lactate dehydrogenase 5 (LDH-5) is one of the major isoenzymes catalyzing the biochemical process of pyruvate to lactate. The purpose of this study was to investigate the expression of serum LDH-5 and test whether this enzyme is regulated by tumor hypoxia and represents a prognostic marker in patients with Non-Hodgkin's lymphoma (NHL). In this study, LDH-5(More)
Hair simulation is known to be a complex problem in animation. In <i>Tangled</i> we have the extreme task of simulating 70 feet of hair for the film's main character, Rapunzel. The excessive hair length in addition to the loose style and intricate structure of the hair present many unique challenges in simulation. Moreover, the specific art direction of the(More)
BACKGROUND To assess prognostic and predictive effects of clinical and biochemical factors in our published randomized study of a weekly low dose (metronomic arm) versus a conventional dosage of zoledronic acid (conventional arm) in breast cancer patients with bone metastases. METHODS Treatment outcome of 60 patients with bone metastases were used to(More)
Lung cancer is the leading cause of cancer-related death in the world. Previous report has identified ribosomal protein s15a (RPS15A) as a TGF-β-responsible gene in the lung adenocarcinoma cell line A549. In this study, we used specific si-RNA to downregulate RPS15A expression in A549 cells and found that decreased RPS15A expression significantly inhibited(More)
  • Si Sun, Hui Yu, +6 authors Jialei Wang
  • 2017
BACKGROUND Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations might develop primary and secondary resistance to tyrosine kinase inhibitors (TKIs). The proapoptotic protein Bcl-2-like 11 (BIM) is a key modulator of apoptosis triggered by EGFR-TKIs. The recent studies have indicated that some patients with(More)