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The purpose of this research is to investigate the effect of tanshinone IIA, an extract of the Chinese medicine Que Xie Hua Yu Tang, on uric acid nephropathy (UAN) and to elucidate the underlying mechanisms. UAN rat model was established. Fifty UAN rats were randomly allocated into 5 groups: adenine-treated group, allopurinol-treated group, and(More)
UNLABELLED There are only nine primitive neuroectodermal tumor (PNET) cases that have arisen in lung parenchyma without pleural or chest wall involvement in the literature. Here, we present a long-term survival case of pulmonary PNET. A pulmonary mass was detected in a 19-year-old man on a chest radiograph and computed tomography image. At the three-year(More)
To investigate whether uric acid could regulate urate transporter 1 (URAT1) protein and activity level, we established uric acid nephropathy (UAN) rat model and detected their serum uric acid and URAT1 level with or without the treatment of allopurinol. Results here showed that allopurinol could reduce serum uric acid level in UAN rat model. We further(More)
OBJECTIVE To study the effect of Shenqi Fuzheng injection on the humoral immunity (IgG IgM IgA), cellular immunity (T-lymphocyte subsets), Superoxide dismutase (SOD). Lpo and Plasma viscosity in the patients with congestive heart failure (CHF). METHODS Sixty patients with CHF, whose heart function belonged to NYHA grade II-IV were randomly divide into two(More)
OBJECTIVE To explore the effect of "Dan Shao Tang" (DST) on mesangial proliferative glomerulonephritis (MsPGN) of deficiency of Yin with damp-heat symptom. METHODS 90 patients with MsPGN of deficiency of Yin with damp-heat symptom were randomly divided into two groups. 54 patients in treatment group were treated with DST and western medicine, and 36(More)
OBJECTIVE To investigate the ameliorative effect on chronic uric acid nephropathy (CUAN) by integrating western and traditional Chinese medicine (IWTCM). METHODS The 136 CUAN patients were divided into two groups at random, the therapy group of 86 patients were treated by Chinese medicine and allopurinol, and the control group of 50 patients were treated(More)
To investigate how organic anion transporter (OAT)-1 is involved in uric acid nephropathy (UAN), a rat model for UAN was established and the serum uric acid, blood urea nitrogen and serum creatinine levels were all measured, and observed to be increased. It was additionally identified that in UAN rats the surface OAT1 expression levels were reduced. By(More)
Osteoporosis is a common disease causing fracture in older populations. Abnormal apoptosis of osteoblasts contributes to the genesis of osteoporosis. Inhibiting apoptosis of osteoblasts provides a promising strategy to prevent osteoporosis. The proliferation of osteoblasts isolated from osteoporotic patients or healthy subjects was determined by MTT assay.(More)
OBJECTIVE To evaluate the clinical study of Zhuyutongmai (ZYTM) Capsule in treating senile cerebral infarction and effect on function of vascular endothelium. METHODS Sixty-four aged patients with cerebral infarction were randomly divided into the treated group treated with ZYTM and the control group treaded with Naoluotong. The clinical effect was(More)
To investigate whether and how organic anion transporter 1 (OAT1) is involved in the process of Alzheimer’s disease (AD), we crossbred OAT1 knockout mice with tg2576, the widely used AD model mice. Results here showed the heterozygous OAT1-deficient tg2576 mice developed a learning- and memory-related behavior deficiency and higher soluble Abeta amount in(More)