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Human embryonic neural stem cell transplantation increases subventricular zone cell proliferation and promotes peri‐infarct angiogenesis after focal cerebral ischemia
It is indicated that NSC transplantation enhances endogenous cell proliferation in the SVZ and promotes angiogenesis in the peri‐infarct zone, even if it is performed in the acute phase of ischemic injury.
The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons
Tetramethylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogen-activated protein kinases pathway in vitro
Activation of Type 4 Metabotropic Glutamate Receptor Attenuates Oxidative Stress-Induced Death of Neural Stem Cells with Inhibition of JNK and p38 MAPK Signaling.
It is suggested that activation of mGluR4 prevents oxidative stress-induced NSC death and apoptotic-associated protein activities with involvement of inhibiting the JNK and p38 pathways in cell culture.
Transplanted human embryonic neural stem cells survive, migrate, differentiate and increase endogenous nestin expression in adult rat cortical peri‐infarction zone
- Pengbo Zhang, J. Li, Yong Liu, Xinlin Chen, Q. Kang
- Biology, MedicineNeuropathology : official journal of the Japanese…
- 1 August 2009
The findings indicate that transplantation of neural stem cells into the peri‐infarction zone may be performed as early as 24 h after ischemia and enhanced endogenous nestin expression within a brief time window.
Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia
The results indicate that TMP could protect ischemic brain damage, and promote cell proliferation and differentiation stimulated by ischemia, which might be related to the reduction of nNOS expression after treatment with TMP in rat cerebral ischemIA model.
Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice
Protective Effect of Minocycline Against Ketamine-Induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 Beta Pathway
The results suggest that PI3K/Akt and Gsk-3β pathway are involved in the neuroprotective effect of MC, which could prevent neuronal cell death through the activation of cell survival signals and the inhibition of apoptotic signals in models of neurodegenerative diseases.
AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways
Selection of housekeeping genes for normalization of RT-PCR in hypoxic neural stem cells of rat in vitro
Two genes, HPRT and RPL13A were identified as the most confidential housekeeping genes in this research by geNorm and NormFinder softwares and validated in this experiment, which might provide a better understanding for the gene expression study in ischemic and necrotic neural stem cell cultures or inIschemic diseases of the central nervous system (CNS).