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Disk space, input/output (I/O) speed, and data-transfer bandwidth present a major bottleneck in large-scale molecular dynamics simulations, which require storing positions and velocities of multimillion atoms. A data compression algorithm is designed for scalable I/O of molecular dynamics data. The algorithm uses octree indexing and sorts atoms accordingly(More)
We have developed a visualization system, named Atomsviewer, to render a billion atoms from the results of a molecular dynamics simulation. This system uses a hierarchical view frustum culling algorithm based on the octree data structure to eff-ciently remove atoms that are outside of the eld of view. A novel occlusion culling algorithm, using a probability(More)
Caspases and inhibitor of apoptosis proteins (IAPs) are antagonizing key apoptosis regulators. Limited studies of a few IAPs indicated their roles in astrocytomas. However, the overall expression status and significance of apoptosis regulators in astrocytomas is not clear. We examined the expression profile of the caspases (CASP3, 6, 7, 8, 9, 10, and 14),(More)
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with high incidence and mortality worldwide. Diallyl disulfide (DADS) is a natural organosulfur compound, isolated from garlic. In this study, MTT assay showed that DADS significantly reduced cell viability in a dose- and time-dependent manner in ESCC cells, with lower toxicity in normal liver(More)
Diallyl disulfide (DADS) is a natural organosulfur compound isolated from garlic. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human esophageal carcinoma have not been elucidated, especially in vivo. In this study, MTT assay showed that DADS significantly(More)
ii ACKNOWLEDGEMENTS This dissertation would not be possible without my major professor Dr. Aiichiro Nakano. It is difficult to overstate my gratitude for his guidance, patience, enthusiasm, encouragement, and persistent support when I needed them most. It is equally an honor and a blessing for being his student. For me, Dr. Nakano is not only a career role(More)
ACKNOWLEDGEMENTS This has been a tremendous experience. I am whelmed with pleasure to recount all the people who have affected my life leading up to this accomplishment. the opportunity to participate as a graduate student in this exciting area of research. I am grateful for the encouragement, generous support and candid advice they have provided me along(More)
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