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Effects of thymosin β4 on oxygen‑glucose deprivation and reoxygenation‑induced injury.
TLDR
The present study was the first to report on the antioxidant, anti-apoptotic and anti-autophagic effects of thymosin β4 in neuronal‑like PC12 cells, and suggested that Tβ4 may be explored as a potential treatment for cerebral ischemia. Expand
Multicolor Raman Beads for Multiplexed Tumor Cell and Tissue Imaging and in Vivo Tumor Spectral Detection.
TLDR
Polymeric nanoparticles with monomers containing alkyne, cyanide, azide, and carbon-deuterate were prepared as Raman-active nanomaterials (Raman beads) for bioimaging applications and targetable Raman beads anchored with targeting moieties were successfully employed to target tumors in living mice after tail intravenous injection. Expand
Differential microRNA expression in the prefrontal cortex of mouse offspring induced by glyphosate exposure during pregnancy and lactation
TLDR
The results indicated abnormalities of the Wnt/β-catenin and Notch pathways, which may be of particular interest for understanding the mechanism of glyphosate-induced neurotoxicity, as well as helping to clarify the association between glyphosate and NDDs. Expand
Circular RNA expression profiles in hippocampus from mice with perinatal glyphosate exposure.
  • N. Yu, Y. Tong, +4 authors Hua Ji
  • Medicine, Biology
  • Biochemical and biophysical research…
  • 2 July 2018
TLDR
Results showed that circRNAs are aberrantly expressed in the hippocampus of mice with perinatal glyphosate exposure and play potential roles in glyphosate-induced neurotoxicity. Expand
Photomodulating Gene Expression by Using Caged siRNAs with Single‐Aptamer Modification
TLDR
It is expected that further optimized caged siRNAs featuring aptamer conjugation will be promising for practical applications to spatiotemporal photoregulation of gene expression in the future. Expand
Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice.
TLDR
Caged siRNA nanoparticles with high serum stability not only show great promise for photoregulation of exogenous and endogenous gene expression for both in vitro and in vivo applications, but also provide a novel and convenient way to spatiotemporally control RNAi-induced gene silencing. Expand
Triton X-100 modified ATP-responsive siRNA delivery agent for antitumor therapy.
TLDR
Triton X-100 modified ATP-responsive transfection agent is a promising gene delivery vector for target gene silencing in vitro and in vivo, and shows significant tumor growth inhibition on mice tumor models. Expand
Photoregulation of Gene Expression with Amantadine-modified Caged siRNAs Through Host/Guest Interaction.
TLDR
Photomodulation of gene silencing activity of these amantadine-modified caged siRNAs targeting both exogenous and endogenous genes was successfully achieved with low leaking activity, which indicated that host/guest interaction could be a new strategy for developing new cagedSiRNAs for gene photoregulation. Expand
Photoregulation of Gene Expression with Ligand‐Modified Caged siRNAs through Host/Guest Interaction
TLDR
A novel caging strategy is described that increases the blocking effect of RISC complex formation/process through host/guest (including ligand/receptor) interactions, thereby enhancing the inhibition of caged siRNA activity until light activation. Expand