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Regulating gene expression with light-activated oligonucleotides.
In the near future, the authors can expect photoresponsive DNA and RNA molecules that are relatively non-toxic, nuclease-resistant, and maintain their specificity and activity in vivo. Expand
Photophysical properties and TPA optical limiting of two new organic compounds
The emission and optical limiting properties of two new organic compounds have been experimentally investigated. Pumping by picosecond and nanosecond lasers, respectively, these two compounds possessExpand
Synthesis and unique photoluminescence properties of nitrogen-rich quantum dots and their applications.
Nitrogen-rich quantum dots (N-dots) were serendipitously synthesized in methanol or aqueous solution at a reaction temperature as low as 50 °C and show unique and distinct photoluminescence properties with an increasing percentage of nitrogen compared to the neighboring carbon dots. Expand
Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
It is demonstrated—in vitro and in vivo—that FTO has extensive demethylation enzymatic activity on both internal m6A and cap m6Am and that the substrate specificity of FTO primarily results from the interaction of residues in the catalytic pocket with the nucleobase. Expand
Two-photon induced fluorescence of novel dyes
Abstract Three novel compounds, trans -2-[ p -( N -ethyl- N -(hydroxyethyl)amino)styryl]- N -methylbenzothiazolium iodide ( 1 ), trans -2-[ p -( N -ethyl- NExpand
Visualizing Hydrogen Sulfide in Mitochondria and Lysosome of Living Cells and in Tumors of Living Mice with Positively Charged Fluorescent Chemosensors.
Two fluorescent chemosenors, Mito-HS and Lyso-HS, were rationally designed and synthesized with positive charge at physiological conditions and showed faster and more efficient fluorescence H2S detection than the similar literature-reported probe without positive charge. Expand
Manipulation of gene expression in zebrafish using caged circular morpholino oligomers
A new design and synthesis of caged circular MOs (caged cMOs) with two ends linked by a photocleavable moiety are reported, successfully used to photomodulate β-catenin-2 and no tail expression in zebrafish embryos. Expand
Sensitive Detection of Single-Nucleotide Mutation in the BRAF Mutation Site (V600E) of Human Melanoma Using Phosphate-Pyrene-Labeled DNA Probes.
These rationally designed ODN probes successfully worked as "turn on" fluorescence oligonucleotide sensors for single-nucleotide polymorphism (SNP) and were used for detecting a single BRAF mutation site (V600E) of human melanoma. Expand
Photosensitive Cross‐linked Block Copolymers with Controllable Release
We intend to form photosensitive block copolymer micelles for controllable release of encapsulated substances. Here, we designed and synthesized a new photocleavable cross‐linker (2‐nitrophenylExpand
Photoregulating RNA digestion using azobenzene linked dumbbell antisense oligodeoxynucleotides.
It is promising to use these azobenzene linked dumbbell antisense oligodeoxynucleotides (asODNs) for reversible spatial and temporal regulation of antisense activities based on both steric binding and RNA digestion by RNase H. Expand