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OBJECTIVES We evaluated the therapeutic potential of a recombinant 61-residue neuregulin-1 (beta2a isoform) receptor-active peptide (rhNRG-1) in multiple animal models of heart disease. BACKGROUND Activation of the erbB family of receptor tyrosine kinases by rhNRG-1 could provide a treatment option for heart failure, because neuregulin-stimulated(More)
A novel rhein formulation based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) suitable for oral administration was developed in this study. The designed nanosystems were obtained by a modified spontaneous emulsification solvent diffusion method. The morphology of rhein-loaded PLGA NPs showed a spherical shape with a smooth surface, without any(More)
During autoimmune disease the fraction of CD4+CD28- T cells in the peripheral blood of has been found to be elevated. In the present study, peripheral blood was collected from 61 patients with Graves' disease (GD) and 30 healthy control participants. Serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4)(More)
OBJECTIVE To evaluate the aesthetic outcomes of all-ceramic restorations by using four different porcelain materials on mimic-tetracycline pigmentation backgrounds. METHODS The translucency parameters (TP) of four different all-ceramic restorations (IPS e.max, Cercon, Lava, and Girrbach) were measured under white and black back grounds by using Datacolor(More)
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