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Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
TLDR
These results provide the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV, and that intermediate hosts may not be necessary for direct human infection by some bat SL-CoVs, and highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots.
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
TLDR
It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs, and highlights the necessity of preparedness for future emergence of Sars-like diseases.
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
TLDR
A potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations is suggested, and robust viral replication both in vitro and in vivo is demonstrated.
Bat origin of human coronaviruses
TLDR
Understanding the bat origin of human coronaviruses is helpful for the prediction and prevention of another pandemic emergence in the future.
Metagenomic Analysis of Viruses from Bat Fecal Samples Reveals Many Novel Viruses in Insectivorous Bats in China
TLDR
This study provides the first preliminary understanding of the virome of some bat populations in China, which may guide the discovery and isolation of novel viruses in the future.
Host Range, Prevalence, and Genetic Diversity of Adenoviruses in Bats
TLDR
The results support the notion, derived from previous studies based on RNA viruses, that bats seem to have the unusual ability to harbor a large number of genetically diverse viruses within a geographic location and/or within a taxonomic group.
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
TLDR
These results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
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