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BACKGROUND The rates of molecular evolution for protein-coding genes depend on the stringency of functional or structural constraints. The Ka/Ks ratio has been commonly used as an indicator of selective constraints and is typically calculated from interspecies alignments. Recent accumulation of single nucleotide polymorphism (SNP) data has enabled the(More)
During cell division, cells form the microtubule-based mitotic spindle, a highly specialized and dynamic structure that mediates proper chromosome transmission to daughter cells. Cancer cells can show perturbed mitotic spindles and an approach in cancer treatment has been to trigger cell killing by targeting microtubule dynamics or spindle assembly. To(More)
Data fusion (or information integration) from different sources is required for many technical fields, including epidemiology, medicine, biology, business, and military applications such as intelligence. Data fusion may involve integration of spectral content with imaging, text, and many other observations or with sensor data. Therefore, any software system(More)
DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor Battelle Memorial Institute, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or(More)
This paper describes the application of modern data analysis systems to prostate cancer research articles. The articles are studied as a group to address the questions: 1. What are the trends in diagnostic and treatment research? 2. Which organizations and individuals are engaged in prostate cancer research, and how has their participation varied over time?(More)
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