Xingya Wang

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Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent member of the transforming growth factor beta (TGF-β) superfamily and mice expressing hNAG-1/hGDF15 have been shown to be resistant to HFD-induced obesity and inflammation. This study investigated if hNAG-1 increases lifespan in mice and its potential mechanisms. Here we(More)
OBJECTIVE Obesity is a major health problem associated with high morbidity and mortality. NSAID-activated gene (NAG-1) is a TGF-β superfamily member reported to alter adipose tissue levels in mice. We investigated whether hNAG-1 acts as a regulator of adiposity and energy metabolism. DESIGN/SUBJECTS hNAG-1 mice, ubiquitously expressing hNAG-1, were placed(More)
OBJECTIVE The NLRP3 inflammasome plays an important regulatory role in obesity-induced insulin resistance. NSAID activated gene-1 (NAG-1) is a divergent member of the TGF-β superfamily. NAG-1 Tg mice are resistant to dietary- and genetic-induced obesity and have improved insulin sensitivity. The objective was to examine whether NLRP3 inflammasome activity(More)
Testing-based Fault Localization (TBFL) can guide and automate the process of program debugging by providing developers with a ranked list of suspicious statements. However, collecting the testing information of the whole original test-suite is always too expensive or even infeasible for developers to conduct efficient TBFL. Traditional Test-Suite Reduction(More)
The recent studies indicate that predicate-based statistical fault localization suffered from the control dependence confounding effect and the failure flow confounding effect, which decrease the measurement accuracy of fault localization. However, the extent of the potentially confounding effect of data dependence is uncertain. This paper presents a novel(More)
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