Xingya Wang

Justin Kosak3
Kali Chrysovergis3
Thomas E. Eling3
3Justin Kosak
3Kali Chrysovergis
3Thomas E. Eling
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  • Xingya Wang, Kali Chrysovergis, Justin Kosak, Grace Kissling, Mike Streicker, Glenda Moser +2 others
  • 2014
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent member of the transforming growth factor beta (TGF-β) superfamily and mice expressing hNAG-1/hGDF15 have been shown to be resistant to HFD-induced obesity and inflammation. This study investigated if hNAG-1 increases lifespan in mice and its potential mechanisms. Here we(More)
OBJECTIVE Obesity is a major health problem associated with high morbidity and mortality. NSAID-activated gene (NAG-1) is a TGF-β superfamily member reported to alter adipose tissue levels in mice. We investigated whether hNAG-1 acts as a regulator of adiposity and energy metabolism. DESIGN/SUBJECTS hNAG-1 mice, ubiquitously expressing hNAG-1, were placed(More)
OBJECTIVE The NLRP3 inflammasome plays an important regulatory role in obesity-induced insulin resistance. NSAID activated gene-1 (NAG-1) is a divergent member of the TGF-β superfamily. NAG-1 Tg mice are resistant to dietary- and genetic-induced obesity and have improved insulin sensitivity. The objective was to examine whether NLRP3 inflammasome activity(More)
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