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Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent member of the transforming growth factor beta (TGF-β) superfamily and mice expressing hNAG-1/hGDF15 have been shown to be resistant to HFD-induced obesity and inflammation. This study investigated if hNAG-1 increases lifespan in mice and its potential mechanisms. Here we(More)
OBJECTIVE Obesity is a major health problem associated with high morbidity and mortality. NSAID-activated gene (NAG-1) is a TGF-β superfamily member reported to alter adipose tissue levels in mice. We investigated whether hNAG-1 acts as a regulator of adiposity and energy metabolism. DESIGN/SUBJECTS hNAG-1 mice, ubiquitously expressing hNAG-1, were placed(More)
OBJECTIVE The NLRP3 inflammasome plays an important regulatory role in obesity-induced insulin resistance. NSAID activated gene-1 (NAG-1) is a divergent member of the TGF-β superfamily. NAG-1 Tg mice are resistant to dietary- and genetic-induced obesity and have improved insulin sensitivity. The objective was to examine whether NLRP3 inflammasome activity(More)
The antitumor effects of nonsteroidal anti-inflammatory drugs (NSAID) are assumed to be due to the inhibition of COX activity, but COX-independent mechanisms may also play an important role. NSAID-activated gene (NAG-1/GDF15) is induced by NSAIDs and has antitumorigenic activities. To determine the contribution of COX-2 inhibition and NAG-1/GDF15 expression(More)
The recent studies indicate that predicate-based statistical fault localization suffered from the control dependence confounding effect and the failure flow confounding effect, which decrease the measurement accuracy of fault localization. However, the extent of the potentially confounding effect of data dependence is uncertain. This paper presents a novel(More)
Testing-based Fault Localization (TBFL) can guide and automate the process of program debugging by providing developers with a ranked list of suspicious statements. However, collecting the testing information of the whole original test-suite is always too expensive or even infeasible for developers to conduct efficient TBFL. Traditional Test-Suite Reduction(More)
  • Kun Na, Kang Li, Tingting Sang, Kaikai Wu, Ying Wang, Xingya Wang
  • 2017
Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention for many years. However, the mechanism by which GLP exerts its chemopreventive activities remains elusive. In addition, it is unclear whether sporoderm-broken spores of G. lucidum water extract (BSGLWE), which contains mainly GLPs, has(More)
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