Xingxing Jin

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The pathophysiological mechanisms leading to dyskinesias in Parkinson’s disease (PD) after long-term treatment with levodopa remain unclear. This study investigates the neuronal firing characteristics of the entopeduncular nucleus (EPN), the rat equivalent of the human globus pallidus internus and output nucleus of the basal ganglia, and its coherence with(More)
Dopamine (DA) depletion in the nigrostriatal system leads to basal ganglia dysfunction both in Parkinson's disease (PD) and in 6-hydroxy dopamine (6-OHDA)-lesioned rats with neuronal hyperactivity in the subthalamic nucleus (STN), i.e. increased firing rate and burst activity, together with enhanced beta oscillatory activity. Moreover, intrastriatal(More)
In this paper, we apply data mining technologies to a 100-year global land precipitation dataset and a 100-year Sea Surface Temperature (SST) dataset. Some interesting teleconnections are discovered, including well-known patterns and unknown patterns (to the best of our knowledge), such as teleconnections between the abnormally low temperature events of the(More)
The function of the nigro-striatal pathway on neuronal entropy in the basal ganglia (BG) output nucleus, i.e. the entopeduncular nucleus (EPN) was investigated in the unilaterally 6-hyroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (PD). In both control subjects and subjects with 6-OHDA lesion of dopamine (DA) the nigro-striatal pathway, a(More)
A low-fouling zwitterionic surface strategy has been proven to be promising and effective for repelling nonspecific adsorption of proteins, cells and bacteria, which may eventually induce adverse pathogenic problems such as thrombosis and infection. Herein, a multi-step process was developed by a combination of mussel-inspired chemistry and(More)
Movement disorders such as Parkinson’s disease (PD) and dystonia are associated with alterations of basal ganglia motor circuits and abnormal neuronal activity in the output nucleus, the globus pallidus internus (GPi). This study aims to compare the electrophysiological hallmarks for PD and dystonia in the linear and non-linear time stamp domains in(More)
High single instruction multiple data (SIMD) efficiency and low power consumption have made graphic processing units (GPUs) an ideal platform for many complex computational applications. Thousands of threads can be created by programmers and grouped into fixed-size SIMD batches, known as warps. High throughput is then achieved by concurrently executing such(More)
Several findings support the concept that sensorimotor integration is disturbed in Parkinson's disease (PD) and in levodopa-induced dyskinesias. In this study, we explored the neuronal firing activity of excitatory pyramidal cells and inhibitory interneurons in the forelimb region of the primary somatosensory cortex (S1FL-Ctx), along with its interaction(More)
Teleconnection is a linkage between two climate events that occur in widely separated regions of the globe on a monthly or longer timescale. In the past, statistical methods have been used to discover teleconnections. However, because of the overwhelming volume and high resolution of datasets acquired by modern data acquisition systems, these methods are(More)