Xingrun Zhang

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DNA methylation is a conserved epigenetic silencing mechanism that functions to suppress the proliferation of transposons and regulate the expression of endogenous genes. In plants, mutations that cause severe loss of DNA methylation result in reactivation of transposons as well as developmental abnormalities. We use the flowering plant Arabidopsis thaliana(More)
Pericentriolar material (PCM) recruitment to centrioles forms a key step in centrosome biogenesis. Deregulation of this process leads to centrosome aberrations causing disorders, one of which is autosomal recessive primary microcephaly (MCPH), a neurodevelopmental disorder where brain size is reduced. During PCM recruitment, the conserved centrosomal(More)
A substantial amount of cytochrome oxidase subunit III (COIII) mRNA continues to be synthesized de novo in Trypanosoma brucei in the presence of actinomycin D, presumably by a DNA-independent transcription process. We describe the identification of negative-strand COIII RNA molecules, characterization of their termini, and the detection of RNA-dependent RNA(More)
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