miR‐223 suppresses differentiation of tumor‐induced CD11b+Gr1+myeloid‐derived suppressor cells from bone marrow cells
Interestingly, miR‐223 remarkably inhibits differentiation of BMCs into CD11b+Gr1+MDSCs in the presence of tumor‐associated factors by targeting myocyte enhancer factor 2C (MEF2C) and its targeting molecule MEF1C increases the number of MDSCs.
Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell Migration and Invasion of Osteosarcoma by Directly Targeting SCAI
- Jian-wei Wang, Xiao-Feng Wu, Xiaoxiang Gu, Xingran Jiang
- Biology, MedicineOncology Research
- 23 September 2019
Evidence is provided that CAF exosomal miR-1228 is able to promote osteosarcoma invasion and migration by targeting SCAI, which may represent a critical therapeutic target for osteosARcoma treatment.
Multiple Tumor-Associated MicroRNAs Modulate the Survival and Longevity of Dendritic Cells by Targeting YWHAZ and Bcl2 Signaling Pathways
Tumors upregulate the expression of multiple microRNAs, which influence the survival and longevity of dendritic cells and can target multiple intracellular signaling molecules to cause the apoptosis of DCs in the tumor environment, which represents a new strategy to improve DC-based immunotherapies against tumors.
Bcl2 Signaling Pathways Dendritic Cells by Targeting YWHAZ and Modulate the Survival and Longevity of Multiple Tumor-Associated MicroRNAs
Tumors use a wide array of immunosuppressive strategies, such as reducing the longevity and survival of dendritic cells (DCs), to diminish immune responses and limit the effect of immunotherapy, to improve DC-based immunotherapies against tumors.