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Purple sweet potato color attenuated NLRP3 inflammasome by inducing autophagy to delay endothelial senescence
Autophagy is a vital negative factor regulating cellular senescence. Purple sweet potato color (PSPC), one type of flavonoid, has been demonstrated to suppress endothelial senescence and restore
Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells
Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in
TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development
TLDR
The results indicate modulating TLR4-RelA-miR-30a signal in Th17 may be a therapeutic target for Th17-mediated neurodegeneration in neuroinflammatory diseases.
Dual effects of heme oxygenase-1 on astrocyte injury induced by hemin in vitro
TLDR
Hemin could dose-dependently up-regulate the expression of heme oxygenase-1 and exerted a protective role on astrocyte damage induced by 5 μM hemin, including increased cell survival rate and anti-apoptotic proteins expression.
Re‐defining the clinicopathological spectrum of neuronal intranuclear inclusion disease
  • Hao Chen, L. Lu, +11 authors Xingshun Xu
  • Medicine
    Annals of clinical and translational neurology
  • 15 September 2020
TLDR
In this study, the symptoms, signs, auxiliary examination, and pathological changes in different systems in NIID patients are evaluated.
Troxerutin Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
TLDR
A new pharmacological activity of the flavonoid troxerutin is discovered against UC, which is conducive to the expansion and application of flavonoids in the treatment of human diseases.
RalA exerts an inhibitory effect on IL-1β/IL-18 secretion by blocking NLRP3 inflammasome activation in levornidazole-treated human THP-1 macrophages.
TLDR
A novel pharmacological mechanism by which RalA/levornidazole inhibits NLRP3 inflammasome activation and IL-1β/IL-18 secretion is clarified.
Paclitaxel-loaded magnetic nanocrystals for tumor neovascular-targeted theranostics: an amplifying synergistic therapy combining magnetic hyperthermia with chemotherapy.
TLDR
Tumor neovascular-targeted Mn-Zn ferrite MNCs are synthesized, which encapsulated paclitaxel (PTX) in a biocompatible PEG-phospholipid layer and surface, simultaneously coupled with a tripeptide of arginine-glycine-aspartic acid (RGD), which provided a broad development prospect in clinical applications.
Clinical value for the detection of fetal chromosomal deletions/duplications by noninvasive prenatal testing in clinical practice
This study was to report the experiences on the clinical value of noninvasive prenatal testing (NIPT) for the screening of fetal chromosomal deletions/duplications.