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The aim of this study was to detect alpha-thalassemia in beta-thalassemia carriers during prenatal screening. During a 12-year prenatal screening program, a total of 158 couples (3.2%) were diagnosed to be the discordant alpha- and beta-thalassemia carriers. Of the 158 beta-thalassemia partners, seven (4.4%) were found to have co-inheritance of(More)
Four Chinese patients with Hb Q-H disease were identified during thalassemia screening. The main hematological characteristics of Hb Q-H disease are that Hb A is absent, and Hb Q-Thailand (also known as G-Taichung, Mahidol, Kurashiki-I and Asabara) accounts for the majority of the total hemoglobin (Hb). The phenotype of this disorder is similar to that of(More)
Beta-thalassemia (thal) is the most common genetic disease and is widely distributed in southern China. Prenatal diagnosis is needed to prevent the birth of thalassemic offspring in couples at-risk. This can be performed in the first or second trimester of pregnancy by DNA analysis using polymerase chain reaction (PCR). As there are more than 30 mutations(More)
OBJECTIVE To control the birth of thalassemic children in Southern China. STUDY DESIGN DNA-based diagnosis was offered on fetal tissues in pregnancies when beta-globin gene mutations were identifiable in both parents using polymerase chain reaction (PCR)-reverse dot blot (RDB) assay. An automated high-performance liquid chromatography (HPLC) system was(More)
The purpose of this study was to investigate changes in apoptosis-related proteins bcl-2 and bax on tumor infiltrating dendritic cells (TIDCs) in human endometrial cancer. Expression of bcl-2 and bax proteins in TIDCs of 52 patients with human endometrial cancer were studied by double-labeling immunehistochemistry and image analysis, respectively. 28 cases(More)
Sex chromosome aneuploidies occur commonly in the general population, with an incidence of 1 in 400 newborns. However, no tests specifically targeting sex chromosomes have been carried out in prenatal diagnosis or newborn screening, resulting in late recognition of these diseases. In this study, a rapid diagnostic method for sex chromosome aneuploidies was(More)
We describe a Chinese patient who was heterozygous for both Hb Q-Thailand [alpha74(EF3)Asp-->His] and Hb E [beta26(B7)Gly-->Asp, GAG-->GTG]. Interaction of the alpha(Q-Thailand) and beta(E) chains leads to a hemoglobin (Hb) variant, namely Hb QE, which differs in electrophoretic mobility and high performance liquid chromatography (HPLC) profiles and in the(More)
Drought assessment is important for developing measures to reduce agricultural vulnerability and thereby secure the livelihoods of those who depend on agriculture. This study uses four global ensemble weather prediction systems: the China Meteorological Administration (CMA), the European Centre for Medium-Range Weather Forecasts (ECMWF), the UK Met Office(More)
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