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The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human. Fission yeast sim1 mutants that alleviate kinetochore domain silencing are defective in Scm3(Sp), the ortholog of budding yeast(More)
Point and regional centromeres specify a unique site on each chromosome for kinetochore assembly. The point centromere in budding yeast is a unique 150-bp DNA sequence, which supports a kinetochore with only one microtubule attachment. In contrast, regional centromeres are complex in architecture, can be up to 5 Mb in length, and typically support many(More)
We demonstrate a new development environment 1 for " Information State Update " dialogue systems which allows non-expert developers to produce complete spoken dialogue systems based only on a Business Process Model (BPM) describing their application (e.g. banking, cinema booking, shopping, restaurant information). The environment includes automatic(More)
We demonstrate the REALL-DUDE system 1 , which is a combination of RE-ALL, an environment for Hierarchical Reinforcement Learning, and DUDE, a development environment for " Information State Update " dialogue systems (Lemon and Liu, 2006) which allows non-expert developers to produce complete spoken dialogue systems based only on a Business Process Model(More)
Kinetochore composition and structure are critical for understanding how kinetochores of different types perform similar functions in chromosome segregation. We used affinity purification to investigate the kinetochore composition and assembly in Schizosaccharomyces pombe. We identified a conserved DASH complex that functions to ensure precise chromosome(More)
Queens Univer s ity Belf a s t, Nor ther n I r ela nd Abstrac t Er r or s ca n occur a t ever y level of a dia logue, f r om the r ecognition of wha t wor ds wer e s poken to the under s ta nding of the intentions behind the wor ds. Our a ppr oa ch to er r or-ha ndling a s s umes tha t er r or s ca nnot be a voided in s poken dia logue a nd tha t it is mor(More)
Advanced spoken dialogue systems incorporate functionalities such as mixed-initiative and cross-domain dialogues. In this paper an object-based approach to cross domain dialogue modelling is described in which service agents representing primary transaction types and support agents representing tasks such as eliciting payment details are selected as(More)
In this article we describe how Java can be used to implement an object-based, cross-domain, mixed initiative spoken dialogue manager (DM). We describe how dialogue that crosses between several business domains can be modelled as an inheriting and collaborating suite of objects suitable for implementation in Java. We describe the main features of the Java(More)
We demonstrate a web-based environment for development and testing of different pedestrian route instruction-giving systems. The environment contains a City Model, a TTS interface, a game-world, and a user GUI including a simulated street-view. We describe the environment and components, the metrics that can be used for the evaluation of pedestrian route(More)