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Point and regional centromeres specify a unique site on each chromosome for kinetochore assembly. The point centromere in budding yeast is a unique 150-bp DNA sequence, which supports a kinetochore with only one microtubule attachment. In contrast, regional centromeres are complex in architecture, can be up to 5 Mb in length, and typically support many(More)
  • Alison L. Pidoux, Eun Shik Choi, Johanna K.R. Abbott, Xingkun Liu, Alexander Kagansky, Araceli G. Castillo +5 others
  • 2009
The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human. Fission yeast sim1 mutants that alleviate kinetochore domain silencing are defective in Scm3(Sp), the ortholog of budding yeast(More)
A number of different approaches have been applied to the treatment of errors in spoken dialogue systems, including careful design to prevent potential errors, methods for on-line error detection, and error recovery when errors have occurred and have been detected. The approach to error handling presented here is premised on the theory of grounding , in(More)
Advanced spoken dialogue systems incorporate functionalities such as mixed-initiative and cross-domain dialogues. In this paper an object-based approach to cross domain dialogue modelling is described in which service agents representing primary transaction types and support agents representing tasks such as eliciting payment details are selected as(More)
In this article we describe how Java can be used to implement an object-based, cross-domain, mixed initiative spoken dialogue manager (DM). We describe how dialogue that crosses between several business domains can be modelled as an inheriting and collaborating suite of objects suitable for implementation in Java. We describe the main features of the Java(More)
We demonstrate a web-based environment for development and testing of different pedestrian route instruction-giving systems. The environment contains a City Model, a TTS interface, a game-world, and a user GUI including a simulated street-view. We describe the environment and components, the metrics that can be used for the evaluation of pedestrian route(More)
We demonstrate a new development environment 1 for " Information State Update " dialogue systems which allows non-expert developers to produce complete spoken dialogue systems based only on a Business Process Model (BPM) describing their application (e.g. banking, cinema booking, shopping, restaurant information). The environment includes automatic(More)
We present a novel approach to Information Presentation (IP) in Spoken Dialogue Systems (SDS) using a data-driven statistical optimisation framework for content planning and attribute selection. First we collect data in a Wizard-of-Oz (WoZ) experiment and use it to build a supervised model of human behaviour. This forms a baseline for measuring the(More)
This paper presents some of the main features of a prototype spoken dialogue manager (DM) that has been incorporated into the DARPA Communicator architecture. Developed in Java, the object components that constitute the DM separate generic from domain-specific dialogue behaviour in the interests of maintainability and extensibility. Confirmation strategies(More)
We demonstrate a spoken dialogue-based information system for pedestrians. The system is novel in combining geographic information system (GIS) modules such as a visibility engine with a question-answering (QA) system, integrated within a dialogue system architecture. Users of the demonstration system can use a web-based version (simulating pedestrian(More)