Synthesis and in vivo SAR study of indolin-2-one-based multi-targeted inhibitors as potential anticancer agents.
- L. Zhang, Qingmei Zheng, +4 authors C. Fan
- Medicine, Chemistry
- European journal of medicinal chemistry
- 23 July 2014
A series of indolin-2-one analogues were designed and synthesized, and all of them exhibited excellent in vitro potency. The structure and in vivo activity or toxicity relationship (in-vivo SAR)… Expand
Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas
Triptolide is a traditional Chinese medicinal herb-derived antineoplastic agent. However, its antitumor activity against gynecologic carcinomas has not yet been well described. It is the purpose of… Expand