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Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor
- Shiying Li, Xinghui Wang, X. Gu
- BiologyMolecular therapy : the journal of the American…
- 14 November 2014
In vivo tests indicated that let-7 inhibition promoted SCs migration and axon outgrowth within a regenerative microenvironment and the inhibitory effect ofLet-7 miRNAs on SCs apoptosis might serve as an early stress response to nerve injury, but this effect seemed to be not mediated through a NGF-dependent pathway.
Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury
It is found that microRNA-1 (miR-1) directly targeted BDNF by binding to its 3′-UTR and caused both mRNA degradation and translation suppression of BDNF, which will contribute to the development of a novel therapeutic strategy for peripheral nerve injury, which overcomes the limitations of direct administration of exogenousBDNF by using miR- 1 to regulate endogenous BDNF expression.
The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes Ntn1 and Dcc during peripheral nerve regeneration
It is found that the Ntn1 and Dcc genes are both robustly up-regulated in the sciatic nerve stump after peripheral nerve injury and the miRs let-7 and miR-9 are involved in regulating neuron pathfinding, extending the understanding of the regulatory pathways active during peripheral nerve regeneration.
Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury
Tau protein is present in Schwann cells and affects their proliferation, migration and differentiation; this finding might expand the understanding of the role of tau in peripheral nerve injury and regeneration.
Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components
The study revealed the dynamic changes of tight junction components after peripheral nerve injury and thus might contribute to the understanding of the molecular mechanisms underlying peripheral nervous system injury and regeneration.
Identification of suitable reference genes for gene expression studies in rat skeletal muscle following sciatic nerve crush injury
- Xinghui Wang, H. Zhao, Jun Ni, Jiacheng Pan, Hao Hua, Yaxian Wang
- BiologyMolecular medicine reports
- 28 March 2019
HPRT1 may be used as a reference gene for the normalization of gene expression data generated by RT-qPCR and was particularly stable in gastrocnemius muscles following rat sciatic nerve crush injury.
Correction: The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes Ntn1 and Dcc during peripheral nerve regeneration.
The results confirmed that downregulating the microRNAs let-7 and miR-9 downregulate the axon-guidance genes Ntn1 and Dcc during peripheral nerve regeneration leads to spontaneous cell death in mice.
Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering
Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury
This review explores peripheral nerve injury-induced changes of peripheral physical barriers, including elevated endoneurial fluid pressure, increased leakage of tracer, decreased barrier-type endothelial cell ratio, and altered distributions and expressions of cellular junctional proteins.
Increased levels of miR-3099 induced by peripheral nerve injury promote Schwann cell proliferation and migration
- Qianyan Liu, Yang Miao, Xinghui Wang, Pan Wang, Zhangchun Cheng, Tianmei Qian
- BiologyNeural regeneration research
- 1 March 2019
It is confirmed that increased miR-3099 level induced by peripheral nerve injury can promote the proliferation and migration of Schwann cells.