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Estrogen plays an important role in the proliferation and progression of breast cancer. The estrogen signal is mediated by the estrogen receptors (ERalpha and ERbeta). ERalpha (estrogen receptor alpha) is an important promoter of growth in breast cancer; however, the role of ERbeta (estrogen receptor beta) in breast cancer is less clear. In this study,(More)
OBJECTIVES The purpose of this study was to evaluate the diagnostic accuracy of prenatal screening for congenital heart disease (CHD) based on a combination of the 4-chamber view and 3-vessel view in an unselected population. METHODS A prospective study on 8025 scanned fetuses was performed. All singleton pregnancies scheduled for routine prenatal(More)
OBJECTIVES The purpose of this study was to estimate the incidence of metabolic syndrome (MS) in a 5-year follow-up adult population in Taiwan who were examined at the Major Health Screening Center, and to assess possible socioeconomic determinants of the syndrome in this sample. METHODS The longitudinal study included 9,389 adults, aged 35-74 years, who(More)
OBJECTIVE To evaluate the impact of the COX-2 gene 8473T>C polymorphism on lung cancer risk in Asians, we conducted a comprehensive meta-analysis. METHODS A literature search was performed using PubMed and other databases before June 2010. We pooled studies according to the variants of 8473T>C and performed separate analyses according to ethnicity,(More)
OBJECTIVE To examine the associations of combined lifestyle factors and physical conditions with cerebrovascular diseases (CBVD) mortality, after accounting for competing risk events, including death from cardiovascular diseases, cancers and other diseases. METHODS Data on 2010 subjects aged over 55 years were finally analyzed using competing risk models.(More)
BACKGROUND/AIMS Specific overexpression in cancer cells and evidence of oncogenic functions make Survivin an attractive target in cancer therapy. The small molecule compound YM155 has been described as the first "Survivin suppressant" but molecular mechanisms involved in its biological activity and its clinical potential remain obscure. Survivin protein(More)
Substantial evidence suggests that type 2 diabetes mellitus (T2DM) is a multi-factorial disease with a strong genetic component. A list of genetic susceptibility loci in populations of European and Asian ancestry has been established in the literature. Little is known on the inter-ethnic contribution of such established functional polymorphic variants. We(More)
We report on the first demonstration of a single-fiber optical tweezer that is utilized to stabilize and control the liquid droplet for dye lasing. In order to trap a liquid droplet with a diameter of 15-30 μm, an annular core micro-structured optical fiber is adopted. By using wavelength division multiplexing technology, we couple a trapping light source(More)
OBJECTIVE To investigate the effectiveness and feasibility of modified single-stage transpedicular decompression, debridement, and posterior instrumentation in treatment of thoracic tuberculosis. METHODS Between January 2005 and December 2009, 22 cases of thoracic tuberculosis were treated with modified single-stage transpedicular decompression,(More)
BACKGROUND Raised blood pressure (BP) is associated with the incidence of metabolic syndrome (MetS). It is unknown if subjects with different BP levels may develop certain components of MetS over time. We investigated the incidence of MetS relative to different levels of BP over a 5-year period in a Chinese population in Tongren Hospital, Beijing. METHODS(More)