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Journals and Conferences
The transition-metal-free lactonization of heteroaryl and alkenyl C-H bonds with carbon dioxide is reported to synthesize important coumarin derivatives in moderate to excellent yields. These redox-neutral reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.
Herein, we report a novel visible-light photoredox system with Pd(PPh3)4 as the sole catalyst to realize the first direct cross-coupling of C(sp3)─H bonds in N-aryl tetrahydroisoquinolines with general unactivated alkyl bromides. Moreover, intra- and inter-molecular alkylations of hetero-arenes were also developped under mild reaction conditions. A variety… (More)