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INTRODUCTION The purpose of this study was to examine the effect of a pulpal revascularization procedure for immature necrotic teeth with apical periodontitis. METHODS Twelve patients, each with an immature permanent tooth with chronic or acute apical periodontitis, were recruited. A triantibiotic mix (ciprofloxacin, metronidazole, and minocycline) was(More)
Thrombin is involved in abnormal proliferation of vascular smooth muscle cells (VSMCs) associated with pathogenic vascular remodeling. Thrombin stimulation results in extracellular signal-regulated kinase (ERK)1/2 activation through transactivation of the epidermal growth factor receptor (EGFR). Here, using specific antibodies and inhibitors, we(More)
The purpose of this study was to evaluate the effect of teeth extraction for orthodontic treatment on the upper airway. Relevant trials assessing the effect of orthodontic extractions on the upper airway were retrieved electronically through PubMed, Embase, Medline, Web of Knowledge, and the Cochrane Library. The processes of literature search, selection,(More)
Parkinson’s disease (PD) is a common neurodegenerative disorder and 16 genetic loci responsible for PD have been identified to date [1, 2]. Mutations in leucine-rich repeat kinase 2 (LRRK2) gene, which results in PARK8-linked PD, are common genetic causes of autosomal dominant PD. Many mutations or variants have been reported in this gene, and six of them(More)
BACKGROUND Interferon alpha-inducible protein 27 (IFI27) is an interferon alpha-inducible protein, which was found to be upregulated in some cancers, such as breast cancer, squamous cell carcinoma, hepatocellular carcinoma, and serous ovarian carcinoma. However, the role of IFI27 in ovarian cancer remains to be elucidated. This study was designed to(More)
OBJECTIVE Vascular smooth muscle cell (VSMC) differentiation, growth and survival, key events in the development of cardiovascular diseases, are under the control of signaling enzymes including extracellular signal regulated kinase 1/2 (ERK 1/2), Akt and epidermal growth factor receptor (EGFR) activation. EGFR trans-activation is known to mediate thrombin-(More)
With heart failure leading the cause of death in the USA (Hunt), biomedical research is fundamental to advance medical treatments for cardiovascular diseases. Animal models that mimic human cardiac disease, such as myocardial infarction (MI) and ischemia-reperfusion (IR) that induces heart failure as well as pressure-overload (transverse aortic(More)
BACKGROUND The molecular signals responsible for maintaining homeostatic control over the periodontal ligament (PDL) are unknown. The purpose of this study is to investigate the role of Wnt signaling in this process using gain- and loss-of-function approaches. METHODS The function of endogenous Wnt signal in the PDL was evaluated in Lrp5(ACT) mice in(More)
Molecular wires are covalently bonded to gold electrodes--to form metal-molecule-metal junctions--by functionalizing each end with a -SH group. The conductance of a wide variety of molecular junctions is studied theoretically by using first-principles density functional theory (DFT) combined with the nonequilibrium Green's function (NEGF) formalism. Based(More)
Floc destruction and its impacts on the dewatering properties in terms of capillary suction time (CST) in the process of using flat-sheet membrane for simultaneous thickening and digestion (MSTD) of waste activated sludge were investigated. A pilot-scale MSTD reactor was used to treat waste activated sludge, and extracellular polymeric substances (EPS),(More)