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Identification of a Bombyx mori gene encoding small heat shock protein BmHsp27.4 expressed in response to high-temperature stress.
Elucidating the mechanisms underlying the response and resistance to high-temperature stress in the Lepidoptera is essential for understanding the effect of high-temperature on the regulation of geneExpand
Great increase in antinociceptive potency of [Leu5]enkephalin after peptidase inhibition.
TLDR
It is shown that amastatin-, captopril-, and phosphoramidon-sensitive enzymes play important roles in the inactivation of short endogenous opioid peptides, such as penta-, hepta-, and octa-peptides, administered intra-third-ventricularly to rats. Expand
Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain
TLDR
The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain. Expand
Activation of supraspinal NMDA receptors by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail-flick test of rats.
TLDR
It is suggested that the activation of the supraspinal NMDA receptors by D-serine leads to the potentiation of the antinociception in the tail-flick test and that endogenous D-Serine could modulate the mu-opioid receptor mediated antinOCiception via the glycine site of the NMDA receptor at the suPRaspinal level. Expand
The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.
TLDR
The present data, together with those obtained from previous studies, clearly show that amastatin-, captopril-, and phosphoramidon-sensitive enzymes play important roles in the inactivation of endogenous opioid peptides, such as [Met(5)]enkephalin-Arg(6)-Phe(7), and dynorphin A (1-8), administered intra-third-ventricularly to rats. Expand
Midazolam attenuates the antinociception induced by d-serine or morphine at the supraspinal level in rats.
TLDR
Observations suggest a functional interaction between the NMDA and benzodiazepine/GABA(A) receptors in the regulation of antinociception at the supraspinal level. Expand