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Inhibitor of differentiation 4 (Id4) plays an important role in tumorigenesis, but its role in cancer chemoresistance remains unclear. Our study showed that Id4 expression in cisplatin-resistant A549/DDP cells was higher than that in parental A549 cells. Moreover, overexpression of Id4 in A549 cells results in cisplatin resistance and apoptosis inhibition,(More)
Assisted reproductive technology (ART) increasingly is associated with long-term side-effects on postnatal development and behaviors. High-throughput gene expression analysis has been extensively used to explore mechanisms responsible for these disorders. Our study, for the first time, provides a comparative proteomic analysis between embryos after in vivo(More)
OBJECTIVE To investigate the feasibility and effectiveness of the modified traction arch of skull (crossbar traction arch) for skull traction in treating cervical spine injury by comparing with traditional traction arch of skull. METHODS Between June 2009 and June 2013, 90 patients with cervical vertebrae fractures or dislocation were treated with(More)
Aim: To explore the expression and clinical significance of Zeb1 and Zeb2 in osteosarcoma (OS). Materials and methods: In our study, we detected the expression of Zeb1 and Zeb2 in 120 cases of OS tissues with immunohistochemistry, and divided the cohort into Zeb1 or Zeb2 high/low expression group according to the cut-off. Moreover, we evaluated the clinical(More)
Human malignant melanoma is a common primary malignant cutaneous tumour derived from transformed epidermal melanocytes. Patients with melanoma have a high rate of mortality due to resistance to chemotherapeutic drugs, a major obstacle to a successful treatment. Several reports have suggested that CD146 plays an important role as a signalling molecule in(More)
OBJECTIVE To review the latest researches of Tenomodulin in tendon tissue engineering, to predict the progress of research and application of Tenomodulin. METHODS The literature concerning Tenomodulin in tendon tissue engineering was collected and analyzed. RESULTS Tenomodulin is a type II transmembrane glycoprotein that can regulate growth of tendon(More)
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