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AIM HLA-B*58:01 is strongly associated with allopurinol-induced severe cutaneous adverse reactions. This study aimed to develop a new and convenient method for HLA-B*58:01 genotyping and to investigate HLA-B*58:01 distribution in different Chinese populations. MATERIALS & METHODS Combining of sequence-specific primers and TaqMan probe, a single-tube(More)
CYP2W1 is an orphan member of the cytochrome P450 superfamily. Recently, CYP2W1 has gained great research interest because of its unknown enzymatic function and tumor-specific expression property. This study aims to investigate the genetic polymorphisms of the CYP2W1 gene in Chinese populations and explore the functions of the detected variants. All of the(More)
O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation was reported to be an independent prognostic and predictive factor in glioma patients who received temozolomide treatment. However, the predictive value of MGMT methylation was recently questioned by several large clinical studies. The purpose of this study is to identify MGMT gene(More)
Motacilla alba is a species of small and passerine songbird in the Family Motacillidae, which is widely distributed. In this study, we determined the complete mitochondrial genome of M. alba. The result showed that the total length of the mitogenome was 16 826 bp and contained 2 ribosomal RNA genes, 22 transfer RNA genes, 13 protein-coding genes, and one(More)
AIM  HLA-B*15:02 screening should be performed to prevent antiepileptic drug induced severe cutaneous adverse reactions in populations of Asian origin. This study aimed to develop fast and reliable HLA-B*15:02 genotyping method and to investigate the distribution of HLA-B*15:02 in different Chinese ethnicities. MATERIALS & METHODS A single-tube multiplex(More)
The Tsinling Tree Toad, Hyla tsinlingensis is a tree frog endemic to the Tsinling–Dabie mountains, with a restricted and patchy distribution that is currently shrinking. Twelve novel polymorphic tetranucleotide microsatellite loci markers were isolated and characterized for H. tsinlingensis. The number of alleles per locus is range from 2 to 10. Values of(More)
HLA-B*57:01 is strongly associated with severe adverse drug reaction induced by the anti-HIV drug abacavir (ABC) and antibiotic flucloxacillin. This study was dedicated to establishing a new method for HLA-B*57:01 genotyping and investigating the HLA-B*57:01 distribution pattern in four Chinese populations. A single-tube duplex real-time polymerase chain(More)
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