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In spaceflight human circadian rhythms and sleep patterns are likely subject to change, which consequently disturbs human physiology, cognitive abilities and performance efficiency. However, the influence of microgravity on sleep and circadian clock as well as the underlying mechanisms remain largely unknown. Placing volunteers in a prone position, whereby(More)
INTRODUCTION The livertaxis of glycyrrhizic acid-conjugated bovine serum albumin (GL-BSA) has been reported in the literature. Now, in this paper, we describe a novel type of drug-targeted delivery system containing 10-hydroxycamptothecin (HCPT) with liver tumor targeting. METHODS First, GL was coupled to BSA then HCPT was encapsulated in GL-BSA by(More)
Vinorelbine tartrate (VLBT), as a kind of high hydrophilic and temperature-induced degradation drug, was prepared into nanoparticles by a desolvation procedure. Bovine serum albumin (BSA), as a drug carrier, was stabilized by chemical cross-linking with glutaraldehyde. Firstly, the optimization process of preparing VLBT-loaded BSA nanoparticles(More)
Precipitation is the only water supply and most important factor affecting vegetation growth on the slopes of semi-arid Loess Plateau of China. Based on precipitation data from 7 synoptic stations in the study area over the period 1957-2012, the trends of precipitation and standardized precipitation index (SPI) were analyzed by using linear regression,(More)
Accurately mapping and monitoring glacier changes over decades is important for providing information to support sustainable use of water resource in arid regions of northwest China. Since 1970, glaciers in the Eastern Altun Mountains showed remarkable recession. Further study is indispensable to indicate the extent and amplitude of glacial change at basin(More)
Treatment options for gestational diabetes (GDM) are limited. In order to better understand mechanisms and improve treatments, appropriate animal models of GDM are crucial. Heterozygous db mice (db/+) present with glucose intolerance, insulin resistance, and increased weight gain during, but not prior to, pregnancy. This makes them an ideal model for GDM.(More)
The importance of accurately monitoring rangeland degradation dynamics over decades is increasing in Linxia rangeland, the birthplace of the Yellow River in China. Since 2000, the Chinese government has implemented the “Grain for Green” program and enforced a grazing ban in Gansu province, one of the most degraded provinces, to mitigate the problem of(More)
The exosome is a complex with exoribonuclease activity that regulates RNA surveillance and turnover. The exosome also plays a role in regulating the degradation of precursor mRNAs to maintain the expression of splicing variants. In Neurospora, the silencing of rrp44, which encodes the catalytic subunit of the exosome, changed the expression of a set of(More)
Motor imagery classification in electroencephalography (EEG)-based brain–computer interface (BCI) systems is an important research area. To simplify the complexity of the classification, selected power bands and electrode channels have been widely used to extract and select features from raw EEG signals, but there is still a loss in classification accuracy(More)
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