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Toxicokinetic study of melamine in the presence and absence of cyanuric acid in rats
TLDR
Co‐administration with CYA leads to the alteration of the kinetic characteristics of MEL, which provides an additional explanation for renal toxicity. Expand
Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
A PCR-based genetic screening experiment targeting the dTDP-glucose-4,6-dehydratase gene revealed that a marine sediment-derived strain, Streptomyces sp. 7-145, had the potential to produceExpand
Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
TLDR
Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains. Expand
Xiakemycin A, a novel pyranonaphthoquinone antibiotic, produced by the Streptomyces sp. CC8-201 from the soil of a karst cave
Xiakemycin A, a novel pyranonaphthoquinone antibiotic, produced by the Streptomyces sp. CC8-201 from the soil of a karst cave
In Vitro Activity of Sodium New Houttuyfonate Alone and in Combination with Oxacillin or Netilmicin against Methicillin-Resistant Staphylococcus aureus
TLDR
Combinations of sub-MIC levels of SNH and oxacillin or netilmicin significantly improved the in vitro antibacterial activity against MRSA compared with either drug alone and the SNH-based combinations showed promise in combating MRSA. Expand
Genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii from Beijing, China
TLDR
The objective of this study was to investigate the genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii clinical isolates from Beijing, China and found that armA was reported to be able to cause high levelAminogly coside resistance to most of the clinical important aminglycosides (gentamicin, amikacin, tobramycin, etc). Expand
In vivo antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic.
TLDR
The results validated the potent efficacy of chinfloxacin in vivo and warrants investigation of its clinical use, as well as confirming its high efficacy in murine systemic and local infections. Expand
Daphnetin: A Novel Anti-Helicobacter pylori Agent
TLDR
It is suggested that daphnetin has good activity against MDR H. pylori, which is related to change of membrane structure, increase of DNA damage and PS translocation, and decrease of H.pylori attachment to GES-1 cells. Expand
Synergistic Effect of Colistin Combined with PFK-158 against Colistin-Resistant Enterobacteriaceae
TLDR
It is reported that the antitumor drug PFK-158 and its analogs PFK -015 and 3PO can exert synergistic effects with colistin against colistIn-resistant Enterobacteriaceae, including mcr-1-positive or high-level-colistin-resistant (HLCR) isolates, as shown by a checkerboard assay. Expand
Synthesis and antibacterial evaluation against resistant Gram-negative bacteria of monobactams bearing various substituents on oxime residue.
TLDR
The combination of 8p and 8r with avibactam as a β-lactamases inhibitor, in a ratio of 1:16, showed a promising synergistic effect against both ESBLs- and NDM-1-producing K. pneumoniae. Expand
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