Xin-ri Zhang

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Clara cell protein (CC16) is an anti-inflammatory protein, which is expressed in the airway epithelium. It is involved in the development of airway inflammatory diseases, including chronic obstructive pulmonary disease and asthma. However, the exact molecular mechanism underlying its anti‑inflammatory action remains to be fully elucidated. The aim of the(More)
BACKGROUND Ventilator induced lung injury (VILI) is a serious complication in the treatment of mechanical ventilating patients, and it is also the main cause that results in exacerbation or death of patients. In this study, we produced VILI models by using glucocorticoid in rats with high tidal volume mechanical ventilation, and observed the content of(More)
OBJECTIVE To probe further the role of neutrophil activation in the lung injury induced by mechanical ventilation. METHODS Thirty-two normal Wistar rats were randomly divided into four groups: control group, low tidal volume group, conventional tidal volume group, and high tidal volume group. The counts of white blood cell (WBC) and neutrophil in(More)
MicroRNAs are small noncoding RNA molecules that regulate gene expression at the post-transcriptional level. Compelling evidence reveals that there is a causative link between microRNAs deregulation and lung cancer development and metastasis. The aim of present study was to explore the function of miR-140-3p in the development and metastasis of lung cancer(More)
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