Xin-jian Yang

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BACKGROUND The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays. METHODS Affymetrix HU133 Plus 2.0 microarrays were used to compare gene expression levels between human(More)
BACKGROUND Dissecting aneurysms of the PCA are difficult to treat with preservation of the parent arteries. We report the clinical and angiographic outcome for 8 patients with dissecting aneurysms located at the P2 segment of the PCA. METHODS In the past 5 years, 8 patients, 2 female and 6 male, presented to our institution with P2 dissecting aneurysms of(More)
A novel cell-targeting, near-infrared light-responsive drug delivery platform based on mesoporous silica-coated gold nanorods that are surface-functionalized with aptamer DNA is constructed. Aptamer DNA is used as both capping and targeting agent. In vitro studies show the feasibility of using this nanocarrier for targeted and noninvasive remote controlled(More)
The purpose of this study was to investigate vessel wall imaging features combined with the luminal shapes of intracranial dissecting aneurysms (IDAs) by using 3 Tesla (3T) high-resolution magnetic resonance imaging (MRI) and digital subtraction angiography (DSA). Sixty-seven patients with 76 IDAs were consecutively enrolled in the study from December 2011(More)
BACKGROUND AND PURPOSE Hemodynamic factors are thought to play an important role in the initiation, growth, and rupture of cerebral aneurysms. However, the hemodynamic features in the residual neck of the partially embolized aneurysms and their influences on recanalization are rarely reported. In this study, we characterized the hemodynamics of partially(More)
BACKGROUND To report our experience with 12 ruptured and 12 unruptured vertebral artery (VA) fusiform aneurysms treated endovascularly using stents. METHODS Three patients were female and 20 patients were male; their mean age was 43·7 (17-77) years. Altogether, 25 stents were placed in 23 patients for 24 fusiform VA aneurysms. RESULTS All patients were(More)
The aim of this work was to evaluate the low molecular weight chitosans (LMWCs) as enhancers of transdermal administration of baicalin, an useful drug for the treatment of atopic dermatitis, viral hepatitis, and HIV infection. Permeation experiments were performed in vitro through mouse skin by using Franz cells. Improved baicalin skin penetration was(More)
BACKGROUND [corrected] Matrix metalloproteinases and TIMPs are potent elastases and collagenases, which regulate the remodeling of vascular and play an important role in the development of cerebral aneurysm. Until now, little quantitative data regarding MMPs and TIMPs exist. METHODS Tissue samples of cerebral aneurysm were obtained from 30 patients who(More)
BACKGROUND Biological markers that can be used to predict the risk of intracranial aneurysms (IAs) are not available. METHODS AND RESULTS To clarify whether circulating microRNAs could be used as biomarkers for IA, we carried out microarray assays in a screening cohort of 40 IA patients (20 unruptured and 20 ruptured) and 20 healthy volunteers. We(More)