Xin-hua Feng

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Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.

Xuexian O. Yang, Roza Nurieva, +10 authors Chen Dong
Immunity
2008

Regulatory T (Treg) and T helper 17 (Th17) cells were recently proposed to be reciprocally regulated during differentiation. To understand the underlying mechanisms, we utilized a Th17 reporter mouse… (More)

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.

Kevin P. Mchugh, Kairbaan M Hodivala-Dilke, +7 authors Steven L Teitelbaum
The Journal of clinical investigation
2000

Osteoclasts express the alphavbeta3 integrin, an adhesion receptor that has been implicated in bone resorption and that is therefore a potential therapeutic target. To assess the role of this… (More)

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

Smad proteins transduce signals for transforming growth factor-β (TGF-β)-related factors. Smad proteins activated by receptors for TGF-β form complexes with Smad4. These complexes are translocated… (More)

Phospho-control of TGF-β superfamily signaling

Katharine H. Wrighton, Xia Lin, Xin-hua Feng
Cell Research
2009

Members of the transforming growth factor-β (TGF-β) family control a broad range of cellular responses in metazoan organisms via autocrine, paracrine, and endocrine modes. Thus, aberrant TGF-β… (More)

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

Ying Zhang, Xin-hua Feng, Ran Wu, Rik Derynck
1996

TRANSFORMING growth factor-β TGF-β is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation1–3. TGF-β-related factors, including BMP-2/4, Dpp… (More)

Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.

Xia Lin, Baohua Sun, +6 authors Xin-hua Feng
Molecular cell
2003

The transcription corepressor CtBP is often recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor. In this study, we demonstrate that CtBP1 was… (More)

Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.

Jae Hyang Lim, Brigid V Stirling, +20 authors Jian-Dong Li
Immunity
2007

Streptococcus pneumoniae (S. pneumoniae) causes high early mortality in pneumococcal pneumonia, which is characterized by acute lung injury (ALI). The molecular mechanisms underlying ALI and the high… (More)

Specificity and Versatility in TGF-β Signaling Through Smads

Xin-hua Feng, Rik Derynck
2010

The TGF-β family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing Smad complex.… (More)

Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.

Suping Zhang, Teng Fei, +7 authors Ye-Guang Chen
Molecular and cellular biology
2007

Smad7 plays an essential role in the negative-feedback regulation of transforming growth factor beta (TGF-beta) signaling by inhibiting TGF-beta signaling at the receptor level. It can interfere with… (More)

Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors.

Katharine H. Wrighton, Xia Lin, Paul B Yu, Xin-hua Feng
The Journal of biological chemistry
2009

Transforming growth factor-beta (TGFbeta) superfamily ligands control a diverse set of cellular processes by activating type I and type II serine-threonine receptor kinases. Canonical TGFbeta… (More)

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