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MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3
This study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3. Expand
Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122.
This finding illustrates a previously uncharacterized miR-122-sequestering mechanism by which HBx-LINE1 promotes hepatic cell EMT-like changes and mouse liver injury. Expand
miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1.
These findings provide the first clues regarding the role of miR-150 as an oncogene in lung cancer through the inhibition of SRCIN1 translation. Expand
miR-203 Inhibits Cell Proliferation and Migration of Lung Cancer Cells by Targeting PKCα
It is demonstrated that the downregulation of PKCα by miR-203 modulates biological processes in lung cancer cells and played a critical role in regulating cell proliferation, apoptosis and migration in lung cancers cells. Expand
BAP1 suppresses lung cancer progression and is inhibited by miR-31
It is found that B AP1 protein levels were dramatically diminished in lung cancer tissues while its mRNA levels did not differ significantly, suggesting that a post-transcriptional mechanism was involved in BAP1 regulation. Expand
The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells
It is demonstrated that miR-16 targeting MAP7 played a critical role in regulating proliferation but not apoptosis and cell cycle progression in cancer cells. Expand
Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Promotes the Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma via Metastatic Tumor Antigen 1 and Mechanistic Target of Rapamycin
  • Zhe Lin, Xin Wan, +9 authors Yun Chen
  • Biology, Medicine
  • Journal of Virology
  • 6 August 2014
It is demonstrated that LMP2A could induce EMT by activating MTA1 at the translational level via activating mTOR signaling and the 4EBP1-eIF4E axis in EMT of nasopharyngeal carcinoma. Expand
miR-193a-3p Functions as a Tumor Suppressor in Lung Cancer by Down-regulating ERBB4*
These findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation. Expand
Involvement of phosphatidylinositol 3-kinase and insulin-like growth factor-I in YXLST-mediated neuroprotection
Treatment of external Qi of YXLST significantly attenuated neuronal death that was induced by 24-h exposure to hydrogen peroxide, and greatly inhibited hydrogenperoxide-induced apoptosis, indicating that external Qi-mediated IGF-I expression and PI3K signaling could be one of the mechanisms in neuroprotection by YXL ST. Expand
The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
The study indicates that miR-342-3p likely plays a pro-apoptotic role in such cells, thereby providing a negative feedback arm to IL-4-dependent macrophage proliferation, and identifies a conserved IL- 4/STAT6-regulated microRNA signature in alternatively activated human and mouse macrophages. Expand