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BindingDB (http://www.bindingdb.org) is a publicly accessible database currently containing approximately 20,000 experimentally determined binding affinities of protein-ligand complexes, for 110 protein targets including isoforms and mutational variants, and approximately 11,000 small molecule ligands. The data are extracted from the scientific literature,(More)
In this paper we design and analyze a class of high order numerical methods to delta function integrals appearing in level set methods in two dimensional case. The methods comprise approximating the mesh cell restrictions of the delta function integral. In each mesh cell the two dimensional delta function integral can be rewritten as a one dimensional(More)
  • Xin Wen
  • 2010
In this paper we propose a class of high order numerical methods to delta function integrals appearing in level set methods in the three dimensional case by extending the idea for designing high order methods to two dimensional delta function integrals in [X. Wen, J. Comput. The methods comprise approximating the mesh cell restrictions of the delta function(More)
Proximal renal tubular acidosis (pRTA) is a syndrome caused by abnormal proximal tubule reabsorption of bicarbonate resulting in metabolic acidosis. Patients with mutations to the SLC4A4 gene (coding for the sodium bicarbonate cotransporter NBCe1), have pRTA, growth delay, ocular defects, and enamel abnormalities. In an earlier report, we provided the first(More)
PURPOSE To shed light on the clinical significance of choroidal folds (CFs) in acute Vogt-Koyanagi-Harada disease (VKH). METHODS Twenty-three acute uveitic VKH patients diagnosed between October 2001 and January 2008 were reviewed retrospectively. RESULTS Twelve (52%) patients had CFs; for patients with CFs, more had poor initial visual acuity (<or= 0.1(More)
We propose a simple well-balanced method named the slope selecting method which is efficient in both steady state capturing and preserving for hyperbolic system with geometrical source terms having concentrations. Physical problems under consideration include the shallow water equations with discontinuous topography, and the quasi-one-dimensional nozzle(More)
We propose two simple well-balanced methods for hyperbolic system with geometrical source terms having concentrations. Physical problems under consideration include the shallow water equations with topography, and the quasi one-dimensional isothermal nozzle flows. These two methods use the numerical fluxes already obtained from the corresponding homogeneous(More)
Nitrotyrosine is one of the post-translational modifications (PTMs) in proteins that occurs when their tyrosine residue is nitrated. Compared with healthy people, a remarkably increased level of nitrotyrosine is detected in those suffering from rheumatoid arthritis, septic shock, and coeliac disease. Given an uncharacterized protein sequence that contains(More)
Extracellular matrix proteins control the formation of the inorganic component of hard tissues including bone, dentin, and enamel. The structural proteins expressed primarily in the enamel matrix are amelogenin, ameloblastin, enamelin, and amelotin. Other proteins, like biglycan, are also present in the enamel matrix as well as in other mineralizing and(More)
Molecular events defining enamel matrix removal during amelogenesis are poorly understood. Early reports have suggested that adaptor proteins (AP) participate in ameloblast-mediated endocytosis. Enamel formation involves the secretory and maturation stages, with an increase in resorptive function during the latter. Here, using real-time PCR, we show that(More)