Xin Wang

Publications55
h-index16
Citations674
Highly Influential Citations23
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Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
TLDR
The small molecule Ailanthone (AIL) is identified as a potent inhibitor of both full-length AR ( AR-FL) and constitutively active truncated AR splice variants (AR-Vs) and is a potential candidate for the treatment of CRPC.
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Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity.
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Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach
TLDR
Plumbagin presented non-time-dependent inhibition of CYP activities in both human and rat liver and the relatively low Ki values of plumbagin in humans would have a high potential to cause the toxicity and drug interactions involving CYP enzymes.
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Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats.
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Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
TLDR
It is demonstrated that inhibition of EP4‐expressing IMCs may offer a potential strategy for enhancing the efficacy of immunotherapy for colorectal cancer.
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Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein.
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Preclinical toxicology and toxicokinetic evaluation of ailanthone, a natural product against castration-resistant prostate cancer, in mice.
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New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
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Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9.
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Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes.
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