Xin Wang

Publications53
h-index16
Citations653
Highly Influential Citations21
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Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
TLDR
The small molecule Ailanthone (AIL) is identified as a potent inhibitor of both full-length AR ( AR-FL) and constitutively active truncated AR splice variants (AR-Vs) and is a potential candidate for the treatment of CRPC.
Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity.
Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach
TLDR
Plumbagin presented non-time-dependent inhibition of CYP activities in both human and rat liver and the relatively low Ki values of plumbagin in humans would have a high potential to cause the toxicity and drug interactions involving CYP enzymes.
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
TLDR
It is demonstrated that inhibition of EP4‐expressing IMCs may offer a potential strategy for enhancing the efficacy of immunotherapy for colorectal cancer.
Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein.
Preclinical toxicology and toxicokinetic evaluation of ailanthone, a natural product against castration-resistant prostate cancer, in mice.
Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9.
Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats.
Design and optimization of novel hydroxamate-based histone deacetylase inhibitors of Bis-substituted aromatic amides bearing potent activities against tumor growth and metastasis.
TLDR
Compound 11b, one of the most potent leads, exhibited nanomolar IC50 values toward inhibition of class I and IIb HDACs as well as sub-micromolar activity against proliferation and migration of breast cancer cells in vitro, and significantly suppressed tumor growth in a breast tumor xenograft mouse model.
Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship.
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