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Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal cell carcinoma (ccRCC). Here we address the question whether ITH increases with malignant progression and can hence be exploited as a prognostic marker. Unexpectedly, precision quantitative image analysis(More)
This article presents research on error detection and prediction algorithms in robotics. Errors, defined as either agent error or Co-net error, are analyzed and compared. Three new error detection and prediction algorithms (EDPAs) are then developed, and validated by detecting and predicting errors in typical pick and place motions of an Adept Cobra 800(More)
The purpose of this article is to review the key emerging innovations in laser and photonics systems as well as their design and integration, focusing on challenges and opportunities for solutions of societal challenges. Developments, their significance, and frontier challenges are explained in advanced manufacturing, biomedicine and healthcare, and(More)
Errors and conflicts exist in many systems. A fundamental question from industries is How can errors and conflicts in systems be eliminated by automation, or can we at least use automation to minimize their damage? The purpose of this chapter is to illustrate a theoretical background and applications of how to automatically prevent errors and conflicts with(More)