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A structurally biased chemical library of pyridazinylpiperazine analogs was prepared in an effort to improve the pharmaceutical and pharmacological profile of the lead compound N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide (BCTC). The library was evaluated for VR1 antagonist activity in capsaicin-induced (CAP) and(More)
Real-time fluorescence imaging of the activity of nucleases in living cells has been a difficult issue because of unintended degradation of the natural oligonucleotides by nontarget nucleases or interactions with other proteins. In this work, we demonstrate two types of highly selective, sensitive, and robust oligonucleotide probes for simultaneous imaging(More)
Development of effective ways to specifically and reversibly block the activity of an enzyme is highly desirable for enhancing the selectivity of enzyme assays. Here we demonstrate a novel approach for selective detection of enzyme activities in complex biological samples by using tailor-made nanoparticles. Employing deoxyribonuclease I (DNase I) as a model(More)
Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycline administration, which leads to a(More)
Wormlike micelles have been observed and explained in a wide variety of different types of surfactants except sulfobetaine ones. Here, we first report branched worms formed by a C22-tailed amidosulfobetaine surfactant-3-(N-erucamidopropyl-N,N-dimethyl ammonium) propane sulfonate (EDAS). Increasing EDAS concentration in the semidilute region increases the(More)
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds(More)
Covalently functionalized multi-walled carbon nanotubes (MWNTs) were prepared by grafting well-defined thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) via click reactions. First, azide-terminated poly(N-isopropylacrylamide) (N3-PNIPAM) was synthesized by reversible addition fragmentation chain-transfer (RAFT) polymerization, and then the N₃-PNIPAM(More)