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OBJECTIVE The aim of this study was to investigate the susceptibility and prognostic implications of the cyclin D1 gene (CCND1) G870A polymorphism to nasopharyngeal carcinomas (NPC) in Han population in Yunnan China. METHODS Two hundred and forty one cases with NPC and 271 matched cancer-free controls were genotyped for the CCND1 G870A polymorphism by(More)
A strain that was capable of transforming the phytosterol in corn flour and soybean flour was isolated from soil and identified as Fusarium moniliforme Sheld. The main transformation product was purified by high performance liquid chromatography (HPLC), and was characterized by nuclear magnetic resonance (NMR), mass spectrum (MS), and infrared spectrum(More)
There are controversies about adverse effects of bisphenol A (BPA), a ubiquitous xenoestrogen, on reproduction and development of male animals. To understand BPA action and assess its risk more completely, we examined the impact of BPA at high doses on the testes of pubertal male Kunming (China) mice. BPA at 0 (control), 160, 480, and 960 mg/kg/day was(More)
Certainty regarding the degree to which organic molecules exchange oxygen with local water during plant cellulose synthesis (p(ex)) is necessary for cellulose oxygen isotope (δ(18)O(cell))-based applications in environmental and ecological studies. However, the currently accepted notion that p(ex) is a constant of ca. 0.42 appears inconsistent with(More)
The catalytic efficiency and pH optimum of Trichoderma reesei endo-beta-1,4-glucanase II were improved by protein engineering. We subjected residue 342 to saturation mutagenesis, and further changed the enzyme by random mutagenesis and two rounds of DNA shuffling. Enzyme variants were purified and characterized. Variant N342V exhibited an optimal activity(More)
Endostatin is a potent endogenous angiogenic inhibitor with implicated antitumor activity. However, efficacy of recombinant human endostatin (rhES) in clinical trials is controversial, and application of rhES in treatment of metastatic melanoma awaits further investigations. This phase II trial evaluated the efficacy and safety of a soluble and stable rhES(More)
Stable oxygen isotope ratio of leaf water (δ(18)O(L)) yields valuable information on many aspects of plant-environment interactions. However, current understanding of the mechanistic controls on δ(18)O(L) does not provide complete characterization of effective path length (L) of the Péclet effect,--a key component of the leaf water model. In this study, we(More)
An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is tedious and labor-intensive activity. Developing an algorithm to predict aging genes will be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Drosophila melanogaster aging genes versus(More)
An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is a tedious and labor-intensive activity. Developing an algorithm to predict aging genes for guiding wet-lab experiment should be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Mus(More)
Automatic evaluation metrics are fundamentally important for Machine Translation, allowing comparison of systems performance and efficient training. Current evaluation met-rics fall into two classes: heuristic approaches, like BLEU, and those using supervised learning trained on human judgement data. While many trained metrics provide a better match against(More)