Xin-Min Li

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Haiyun Xu48
Jiming Kong42
Jue He40
Joseph D. Buxbaum29
Yanbo Zhang28
52Jiming Kong
49Jue He
49Haiyun Xu
30Yanbo Zhang
20Shenghua Zhu

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1985
2017
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Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination.
The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2 -weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone-fed (n = 5) mice, with significant increases in signal intensity in T2 -weighted… (More)
Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.
Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, antipsychotic drugs may influence a variety of functions regulating neuronal resilience and viability and have the potential for neuroprotection. This article… (More)
Dose-related effects of chronic antidepressants on neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampus.
It has been proposed that antidepressants have neuroprotective effects on hippocampal neurons. To further test this hypothesis, brain-derived neurotrophic factor (BDNF), B cell lymphoma protein-2 (Bcl-2), and copper-zinc superoxide dismutase (Cu/Zn-SOD) were examined immunohistochemically in hippocampal neurons of Sprague-Dawley rats following daily… (More)
Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks.
OBJECTIVE Diminished cholesterol efflux activity of apolipoprotein B (apoB)-depleted serum is associated with prevalent coronary artery disease, but its prognostic value for incident cardiovascular events is unclear. We investigated the relationship of cholesterol efflux activity with both prevalent coronary artery disease and incident development of major… (More)
Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice.
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the central nervous system. Current approaches for AD treatment only ameliorate symptoms. Therapeutic strategies that target the pathological processes of the disease remain elusive. Fluoxetine (FLX) is one of the most widely used antidepressants for the treatment of depression and… (More)
Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice.
The chronic stress model was developed on the basis of the stress-diathesis hypothesis of depression. However, these behavioural responses associated with different stress paradigms are quite complex. This study examined the effects of two chronic stress regimens on anxiety-like and depressive behaviours. C57BL/6 mice were subjected to unpredictable chronic… (More)
Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of African rice.
Global warming threatens many aspects of human life, for example, by reducing crop yields. Breeding heat-tolerant crops using genes conferring thermotolerance is a fundamental way to help deal with this challenge. Here we identify a major quantitative trait locus (QTL) for thermotolerance in African rice (Oryza glaberrima), Thermo-tolerance 1 (TT1), which… (More)
Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs.
Typical and atypical antipsychotic drugs, though both effective, act on different neurotransmitter receptors and are dissimilar in some clinical effects and side effects. The typical antipsychotic drug haloperidol has been shown to cause a decrease in the expression of brain-derived neurotrophic factor (BDNF), which plays an important role in neuronal cell… (More)
Excessive autophagy contributes to neuron death in cerebral ischemia.
AIMS To determine the extent to which autophagy contributes to neuronal death in cerebral hypoxia and ischemia. METHODS We performed immunocytochemistry, western blot, cell viability assay, and electron microscopy to analyze autophagy activities in vitro and in vivo. RESULTS In both primary cortical neurons and SH-SY5Y cells exposed to oxygen and… (More)
Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.
C57BL/6 mice were given 0.2% cuprizone (CPZ) for 2 to 6 weeks while controls ate the same diet without CPZ. At various time points the animals were subjected to behavioral tests and their brains were analyzed. Mice exposed to CPZ for 2 and 3 weeks displayed more climbing behavior and lower prepulse inhibition, suggesting an increase in central nervous… (More)