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Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus
TLDR
Results of the human study suggest that, compared to control subjects without immune-mediated diseases, SLE patients with active lupus disease possessed an altered gut microbiota that differed in several particular bacterial species and was less diverse, with increased representation of Gram-negative bacteria. Expand
Dynamics of Gut Microbiota in Autoimmune Lupus
TLDR
The dynamics of gut microbiota in murine lupus are demonstrated and evidence is provided to suggest the use of probiotic lactobacilli and retinoic acid as dietary supplements to relieve inflammatory flares in l upus patients. Expand
Leaky Gut As a Danger Signal for Autoimmune Diseases
TLDR
It is hypothesized that modulating the gut microbiota can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals. Expand
Control of lupus nephritis by changes of gut microbiota
TLDR
These beneficial effects were present in female and castrated male mice, but not in intact males, suggesting that the gut microbiota controls lupus nephritis in a sex hormone-dependent manner, and demonstrates essential mechanisms on how changes of the Gut microbiota regulate l upus-associated immune responses in mice. Expand
Role of Lactobacillus reuteri in Human Health and Diseases
TLDR
Inflammatory diseases, including those located in the gut as well as in remote tissues, may be ameliorated by increasing the colonization of L. reuteri, which may be an attractive preventive and/or therapeutic avenue against inflammatory diseases. Expand
Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.
TLDR
The results suggest that an HIV vaccine might be delivered by autologous transplantation of in vitro-programmed HSPCs, which would develop into antibody-secreting B cells in vivo and provide a continuous supply of anti-HIV neutralizing antibodies. Expand
Host adaptive immunity alters gut microbiota
TLDR
The results suggest that adaptive immunity has a pervasive role in regulating gut microbiota’s composition and diversity and that Rag1−/− mice had a higher gain in microbiota richness and evenness with increase in age compared with wild-type mice, possibly due to the lack of pressure from the adaptive immune system. Expand
Antibiotics ameliorate lupus-like symptoms in mice
TLDR
It is reported that oral antibiotics given during active disease removed harmful bacteria from the gut microbiota and attenuated SLE-like disease in lupus-prone mice and showed that antibiotics given after disease onset ameliorated systemic autoimmunity and kidney histopathology. Expand
SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
TLDR
The available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis is compiled to shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies. Expand
Chemokines and Chemokine Receptors in the Development of Lupus Nephritis
TLDR
Recent studies on the roles of chemokines and chemokine receptors in the development of lupus nephritis are summarized and the potential and hurdles of developing novel, Chemokine-based drugs to treat LN are discussed. Expand
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