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This paper reports a controlled study with statistical signi cance tests on ve text categorization methods: the Support Vector Machines (SVM), a k-Nearest Neighbor (kNN) classi er, a neural network (NNet) approach, the Linear Leastsquares Fit (LLSF) mapping and a Naive Bayes (NB) classier. We focus on the robustness of these methods in dealing with a skewed(More)
In this paper, we propose a novel document clustering method based on the non-negative factorization of the term-document matrix of the given document corpus. In the latent semantic space derived by the non-negative matrix factorization (NMF), each axis captures the base topic of a particular document cluster, and each document is represented as an additive(More)
In this paper, we propose two generic text summarization methods that create text summaries by ranking and extracting sentences from the original documents. The first method uses standard IR methods to rank sentence relevances, while the second method uses the latent semantic analysis technique to identify semantically important sentences, for summary(More)
The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after(More)
Purple acid phosphatases (PAPs) are members of the metallo-phosphoesterase family. They are characterized by the presence of seven conserved amino acid residues involved in coordinating the dimetal nuclear center in their reactive site. We compared the 29 PAPs predicted for Arabidopsis thaliana in their varieties of potential metal-ligating residues.(More)
Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical(More)
Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null mutations into both Epo and the EPO receptor (EpoR) gene. Both heterozygotes appeared normal. Homozygous animals exhibited reduced primitive erythropoiesis and died around embryonic day 13, owing to failure of definitive fetal liver(More)
This paper presents the design and implementation of a filter-based DoS defense system (StopIt) and a comparison study on the effectiveness of filters and capabilities. Central to the StopIt design is a novel closed-control, open-service architecture: any receiver can use StopIt to block the undesired traffic it receives, yet the design is robust to various(More)
This study investigates the determinants of Chinese outward direct investment (ODI) and the extent to which three special explanations (capital market imperfections, special ownership advantages and institutional factors) need to be nested within the general theory of the multinational firm. We test our hypotheses using official Chinese ODI data collected(More)
Bread wheat (Triticum aestivum, AABBDD) is one of the most widely cultivated and consumed food crops in the world. However, the complex polyploid nature of its genome makes genetic and functional analyses extremely challenging. The A genome, as a basic genome of bread wheat and other polyploid wheats, for example, T. turgidum (AABB), T. timopheevii (AAGG)(More)