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We present Dionysus, a system for fast, consistent network updates in software-defined networks. Dionysus encodes as a graph the consistency-related dependencies among updates at individual switches, and it then dynamically schedules these updates based on runtime differences in the update speeds of different switches. This dynamic scheduling is the key to(More)
Recently, there has been considerable interest in attribute based access control (ABAC) to overcome the limitations of the dominant access control models (i.e, discretionary-DAC, mandatory-MAC and role based-RBAC) while unifying their advantages. Although some proposals for ABAC have been published, and even implemented and standardized, there is no(More)
Item-based Collaborative Filtering (CF) algorithms have been designed to deal with the scalability problems associated with traditional user-based CF approaches without sacrificing recommendation or prediction accuracy. Item-based algorithms avoid the bottleneck in computing user-user correlations by first considering the relationships among items and(More)
The ability to learn new skills and perfect them with practice applies not only to physical skills but also to abstract skills, like motor planning or neuroprosthetic actions. Although plasticity in corticostriatal circuits has been implicated in learning physical skills, it remains unclear if similar circuits or processes are required for abstract skill(More)
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected by a number of debilitating neurological disorders. The prevailing model of basal ganglia function proposes that two orthogonal projection circuits originating from distinct populations of spiny projection neurons (SPNs) in the striatum--the so-called direct and(More)
Information networks are ubiquitous in many applications and analysis on such networks has attracted significant attention in the academic communities. One of the most important aspects of information network analysis is to measure similarity between nodes in a network. SimRank is a simple and influential measure of this kind, based on a solid theoretical(More)
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were(More)
Targeted capture combined with massively parallel exome sequencing is a promising approach to identify genetic variants implicated in human traits. We report exome sequencing of 200 individuals from Denmark with targeted capture of 18,654 coding genes and sequence coverage of each individual exome at an average depth of 12-fold. On average, about 95% of the(More)
De novo mutation plays an important role in autism spectrum disorders (ASDs). Notably, pathogenic copy number variants (CNVs) are characterized by high mutation rates. We hypothesize that hypermutability is a property of ASD genes and may also include nucleotide-substitution hot spots. We investigated global patterns of germline mutation by whole-genome(More)
— SpiNNaker is a novel chip – based on the ARM processor – which is designed to support large scale spiking neural networks simulations. In this paper we describe some of the features that permit SpiNNaker chips to be connected together to form scalable massively-parallel systems. Our eventual goal is to be able to simulate neural networks consisting of 10(More)