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We present Dionysus, a system for fast, consistent network updates in software-defined networks. Dionysus encodes as a graph the consistency-related dependencies among updates at individual switches, and it then dynamically schedules these updates based on runtime differences in the update speeds of different switches. This dynamic scheduling is the key to(More)
Recently, there has been considerable interest in attribute based access control (ABAC) to overcome the limitations of the dominant access control models (i.e, discretionary-DAC, mandatory-MAC and role based-RBAC) while unifying their advantages. Although some proposals for ABAC have been published, and even implemented and standardized, there is no(More)
Information networks are ubiquitous in many applications and analysis on such networks has attracted significant attention in the academic communities. One of the most important aspects of information network analysis is to measure similarity between nodes in a network. SimRank is a simple and influential measure of this kind, based on a solid theoretical(More)
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were(More)
Item-based Collaborative Filtering (CF) algorithms have been designed to deal with the scalability problems associated with traditional user-based CF approaches without sacrificing recommendation or prediction accuracy. Item-based algorithms avoid the bottleneck in computing user-user correlations by first considering the relationships among items and(More)
Here we integrate the de novo assembly of an Asian and an African genome with the NCBI reference human genome, as a step toward constructing the human pan-genome. We identified approximately 5 Mb of novel sequences not present in the reference genome in each of these assemblies. Most novel sequences are individual or population specific, as revealed by(More)
The ability to learn new skills and perfect them with practice applies not only to physical skills but also to abstract skills, like motor planning or neuroprosthetic actions. Although plasticity in corticostriatal circuits has been implicated in learning physical skills, it remains unclear if similar circuits or processes are required for abstract skill(More)
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected by a number of debilitating neurological disorders. The prevailing model of basal ganglia function proposes that two orthogonal projection circuits originating from distinct populations of spiny projection neurons (SPNs) in the striatum--the so-called direct and(More)
De novo mutation plays an important role in autism spectrum disorders (ASDs). Notably, pathogenic copy number variants (CNVs) are characterized by high mutation rates. We hypothesize that hypermutability is a property of ASD genes and may also include nucleotide-substitution hot spots. We investigated global patterns of germline mutation by whole-genome(More)