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Adult-onset hypothyroidism causes cognitive dysfunctions of learning and memory, in which many synaptic proteins in hippocampus are involved. In our work, we studied the effect of adult-onset hypothyroidism on the expression of synaptotagmin 1 (syt 1) and SNAP-25 in dorsal hippocampus as well as its recovery by levothyroxine (L-T(4)) replacement therapy.(More)
Thyroid hormone insufficiency in adulthood causes a wide range of brain impairments, including altered synaptic proteins in the prefrontal cortex (PFC). The present study investigated whether adult-onset hypothyroidism altered the expression of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes and synaptotagmin-1(More)
Interconnect delay is becoming a major roadblock to FPGA performance with technology scaling and growing chip sizes. Globally Asynchronous Locally Synchronous (GALS) design is considered a potential solution to this issue. An important design decision in building a GALS FPGA architecture is to determine the appropriate GALS island size. A large GALS island(More)
Hepatic stellate cell (HSC) activation is a key cellular event in the development of liver fibrosis. Peroxisome proliferator-activated receptor-gamma (PPARgamma) has been shown to function as a key transcription regulator linked to suppressing HSC activation. Compelling evidence indicates that leptin plays a unique role in the development of liver fibrosis.(More)
This paper proposes GAPLA: a Globally Asynchronous Locally Synchronous Programmable Logic Array architecture. The whole FPGA area is divided into locally synchronous blocks wrapped with asynchronous I/O interfaces. Data communications between synchronous blocks are controlled by 2-phase handshaking signals under bundled-data delay assumption. The size and(More)
Routing delays dominate other delays in current FPGA designs. We have proposed a novel Globally Asynchronous Locally Synchronous (GALS) FPGA architecture called the GAPLA to deal with this problem. In the GAPLA architecture, The FPGA area is divided into locally synchronous blocks and the communications between them are through asynchronous I/O interfaces.(More)
Defining and quantifying biomass–density relationships in dense plant stands has been a long-standing issue in both theoretical and empirical studies. Most existing/traditional studies focus on whole plant individuals, without considering different plant components (e.g., stem, branch and leaf). However, the analysis of biomass–density relationships for(More)