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Photosensitizers in photodynamic therapy allow for the transfer and translation of light energy into a type II chemical reaction. In clinical practice, photosensitizers arise from three families-porphyrins, chlorophylls, and dyes. All clinically successful photosensitizers have the ability to a greater or lesser degree, to target specific tissues or their(More)
We constructed an automated reflectometry system for accurate measurement of coherent reflectance curves of turbid samples and analyzed the presence of coherent and diffuse reflection near the specular reflection angle. An existing method has been validated to determine the complex refractive indices of turbid samples on the basis of nonlinear regression of(More)
The refractive index of human skin tissues is an important parameter in characterizing the optical response of the skin. We extended a previously developed method of coherent reflectance curve measurement to determine the in vitro values of the complex refractive indices of epidermal and dermal tissues from fresh human skin samples at eight wavelengths(More)
Reflectance imaging of biological tissues with visible and near-infrared light has the significant potential to provide a noninvasive and safe imaging modality for diagnosis of dysplastic and malignant lesions in the superficial tissue layers. The difficulty in the extraction of optical and structural parameters lies in the lack of efficient methods for(More)
We introduce an inverse method for determining simultaneously the real and imaginary refractive indices of microspheres based on integrating sphere measurements of diffuse reflectance and transmittance, and Monte Carlo modelling in conjunction with the Mie theory. The results for polystyrene microspheres suspended in water are presented.
We introduce a method with which to obtain accurately the bulk optical parameters of fresh biological tissues in vitro by combining measurements of the sample surface profiles, reflectance, and transmittances with Monte Carlo-based inverse calculations. The bulk optical parameters of fresh porcine dermis tissue were determined at eight wavelengths from 325(More)
BACKGROUND The purpose of this study was to analyze "small world" characteristics in glioma patients in order to understand the relationship between cognitive dysfunction and brain functional connectivity network in the resting state. METHODS Resting-state magnetoencephalography was performed in 20 patients with glioma and 20 healthy subjects. The(More)
The lack of a primary method for determination of optical parameters remains a significant barrier in optical study of turbid media. We present a complete system of experimental setups and Monte Carlo modeling tools for fast and accurate solution of the inverse problem from the measured signals of homogeneous turbid samples. The calibration of the(More)
—Comprehension of biological tissue ablation by short laser pulses in a broad optical spectrum is of fundamental importance to the understanding of laser-tissue interaction and advancing surgical applications of lasers. We report a new plasma ablation model in which the chromophore ionization pathway is incorporated to explain the skin tissue ablation by(More)
Numerical simulations of light scattering by a biconcave shaped human red blood cell (RBC) are carried out using the finite-difference time-domain (FDTD) method. A previously developed FDTD code for the study of light scattering by ice crystals is modified for the current purpose and it is validated against Mie theory using a spherically shaped RBC.(More)