Xin-Hua Hu

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Numerical simulations of light scattering by a biconcave shaped human red blood cell (RBC) are carried out using the finite-difference time-domain (FDTD) method. A previously developed FDTD code for the study of light scattering by ice crystals is modified for the current purpose and it is validated against Mie theory using a spherically shaped RBC.(More)
Photon propagation in biological tissue can be equivalently modeled with Monte Carlo simulations numerically or by the Radiative Transfer Equation (RTE) analytically. However, testing of a Monte Carlo program modeling photon propagation in biological tissue is difficult due to the unknown character of the test oracles. Although approaches based on(More)
A parallel Finite-Difference-Time-Domain (FDTD) code has been developed to numerically model the elastic light scattering by biological cells. Extensive validation and evaluation on various computing clusters demonstrated the high performance of the parallel code and its significant potential of reducing the computational cost of the FDTD method with low(More)
Reflectance imaging of biological tissues with visible and near-infrared light has the significant potential to provide a noninvasive and safe imaging modality for diagnosis of dysplastic and malignant lesions in the superficial tissue layers. The difficulty in the extraction of optical and structural parameters lies in the lack of efficient methods for(More)
One of the grand challenges for adequately testing scientific software is due to the oracle problem. Metamorphic testing is the promise technique for addressing the problem through checking the satisfaction of a metamorphic relation that defines the correlation on the relation of paired test inputs and the one of their corresponding outputs. Therefore,(More)
Human B-cells play an important role in the immune system, and because of their relatively simple structures with a nearly spherically shaped cell membrane and a large nucleus, they provide a good case to study on how the details of cell structure affect light scattering properties. A finite-difference-time-domain (FDTD) method is used to calculate(More)
BACKGROUND In the clinical trial setting, oral rizatriptan 10 mg has greater efficacy than other oral triptans in freedom from migraine headache pain 2 h after dosing. OBJECTIVE The study objective is to compare the effectiveness of rizatriptan 10 mg and other oral triptans for acute migraine attack in a naturalistic setting. METHODS A total of 673(More)
Automated classification of biological cells according to their 3D morphology is highly desired in a flow cytometer setting. We have investigated this possibility experimentally and numerically using a diffraction imaging approach. A fast image analysis software based on the gray level co-occurrence matrix (GLCM) algorithm has been developed to extract(More)
Flow cytometry is an ever-advancing high-throughput multivariate analysis tool that natively provides size and morphological information. To obtain molecular information, however, typically requires the addition of fluorophores, which are limited by spectral overlap, non-specific binding, available conjugation chemistries, and cellular toxicity. A(More)