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Proinflammatory Stimuli Engage Brahma Related Gene 1 and Brahma in Endothelial Injury
Rationale: Endothelial dysfunction inflicted by inflammation is found in a host of cardiovascular pathologies. One hallmark event in this process is the aggregation and adhesion of leukocyte to theExpand
MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex
ABSTRACT Chronic inflammation underscores the pathogenesis of a range of human diseases. Lipopolysaccharide (LPS) elicits strong pro-inflammatory responses in macrophages through the transcriptionExpand
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection. SIRT1 expression is downregulated inExpand
MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis.
Transforming growth factor (TGF-β) induced activation of portal fibroblast cells serves as a primary cause for liver fibrosis following cholestatic injury. The underlying epigenetic mechanism is notExpand
MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response
Macrophage-dependent inflammatory response is considered a pivotal biological process that contributes to a host of diseases when aberrantly activated. The underlying epigenetic mechanism is notExpand
A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy.
  • X. Weng, Liming Yu, +8 authors Y. Xu
  • Biology, Medicine
  • Journal of molecular and cellular cardiology
  • 1 May 2015
Angiotensin II (Ang II) induces cardiac hypertrophy and fibrosis in part by stimulating endothelin (ET-1) transcription. The involvement of the epigenetic machinery in this process is largelyExpand
SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia–reperfusion injury
Ischemic reperfusion (I/R) contributes to deleterious cardiac remodeling and heart failure. The deacetylase SIRT1 has been shown to protect the heart from I/R injury. We examined the mechanismExpand
MKL1 is an epigenetic mediator of TNF‐α‐induced proinflammatory transcription in macrophages by interacting with ASH2
Tumor necrosis factor alpha (TNF‐α) is a prototypical proinflammatory cytokine that can elicit strong inflammation in macrophages by activating NF‐κB. The underlying epigenetic mechanism is obscure.Expand