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To study the effect of endostar on the expression of hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) and radiosensitization, the changes of A549 cells treated by endostar, radiotherapy and radiotherapy plus endostar were checked by flow cytometry (FCM), methyl thiazolyl tetrazolium (MTT), hoechst staining, and enzyme linked(More)
We utilized CT image fusion technique for replanning during the course of three-dimensional conformal radiotherapy (3D-CRT), and determined its dosimetric effects on both target volumes and normal tissues. Ten patients with non-small-cell lung cancer (NSCLC) were studied. The primary treatment plan was generated from the pre-treatment planning CT scan. Two(More)
The mechanisms of radiation-induced effects in cancer mainly involve double-strand breaks (DSBs) which are important in maintaining the stability of genes. The DNA repair genes breast cancer 1 (BRCA1) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are capable of maintaining genetic stability through two distinct and complementary repair(More)
Long non-coding RNAs (lncRNAs) have been identified as critical players in multiple cancers and lncRNAs are tightly linked to cancer progression. However, only little amount of lncRNAs have been identified to participate in the molecular mechanisms of the progression of hepatocellular carcinoma. In this study, we found that lncRNA-AK058003 is down-regulated(More)
Hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) play important roles in tumor angiogenesis. We examined the effect of endostar, an inhibitor of angiogenesis on the expression of HIF-1 and VEGF and on angiogenesis and radio sensitization. Flow cytometry (FCM) was used to evaluate the cell cycle phase distribution affected by(More)
We proposed an intensity-modulated radiotherapy (IMRT) technique: whole-field (WF) IMRT combined with replanning split-field (SF) IMRT in treating nasopharyngeal carcinoma (NPC) patients with the disease above the level of the larynx, and investigated its dosimetric consequences. Ten NPC patients were studied. Repeat CT imaging and replanning were performed(More)
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