Xiling Sun

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Both phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) signaling cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis of tumor cells. In the present report, we investigated the effects of licochalcone A (LA), a flavonoid extracted from licorice root, on the PI3K/AKT/mTOR and MAPK(More)
The proliferation of GPS-enabled devices, and the rapid improvement of scientific instruments have resulted in massive amounts of spatial data in the last decade. Support of high performance spatial queries on large volumes data has become increasingly important in numerous fields, which requires a scalable and efficient spatial data warehousing solution as(More)
This study evaluates antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. (DML). The total flavonoids showed remarkable scavenging effects against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals in vitro. Compared with the ischemia/reperfusion (I/R) group as demonstrated by the use of(More)
Software defects which are detected by black box testing (called black-box defect) are very large due to the wide use of black-box testing, but we could not find a defect classification which is specifically applicable to them in existing defect classifications. In this paper, we present a new defect classification scheme named ODC-BD (Orthogonal Defect(More)
Licochalcone A (LCA), a licorice chalconoid, is considered to be a bioactive agent with chemopreventive potential. This study investigated the mechanisms involved in LCA-induced apoptosis in human bladder cancer T24 cells. LCA significantly inhibited cells proliferation, increased reactive oxygen species (ROS) levels, and caused T24 cells apoptosis.(More)
Solid-state drives (SSDs) are an attractive alternative to hard disk drives (HDDs) to accelerate the Hadoop MapReduce Framework. However, the SSD characteristics and today’s Hadoop framework exhibit mismatches that impede indiscriminate SSD integration. This paper explores how to optimize a Hadoop MapReduce Framework with SSDs in terms of performance, cost,(More)
The aim of this study was to evaluate the antitumour activities and genotoxic effects of isoliquiritigenin (ISL) combined with cyclophosphamide (CP) in vitro and in vivo. U14 cells were treated with either of ISL (5-25 μg/mL) or CP (0.25-1.25 mg/mL) alone or with combination of ISL (5-25 μg/mL) and CP (1.0 mg/mL) for 48 h. The proliferation inhibitory(More)
Defect number prediction is essential to make a key decision on when to stop testing. For more applicable and accurate prediction, we propose an ensemble prediction model based on stacked generalization (PMoSG), and use it to predict the number of defects detected by third-party black-box testing. Taking the characteristics of black-box defects and causal(More)