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Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels.
The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system forExpand
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Honokiol protects brain against ischemia–reperfusion injury in rats through disrupting PSD95–nNOS interaction
Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe theExpand
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Auxiliary KChIP4a Suppresses A-type K+ Current through Endoplasmic Reticulum (ER) Retention and Promoting Closed-state Inactivation of Kv4 Channels*
Background: Compared with other auxiliary KChIPs that enhance Kv4 current, KChIP4a inhibits Kv4 function. Results: We identified an ER retention motif and an adjacent VKL motif within the KChIP4a NExpand
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Physiological and morphological characterization of GABAergic neurons in the medial amygdala
GABAergic neurons in the medial amygdala (MeA) have been indicated in information processing in reproductive behavior and fear/anxiety. However, basic knowledge of their physiological andExpand
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Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice
BackgroundDysfunction of brain-gut interaction is thought to underlie visceral hypersensitivity which causes unexplained abdominal pain syndromes. However, the mechanism by which alteration of brainExpand
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Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice.
A series of novel thiazolo[4,5- d]pyrimidin-7(6 H)-ones (3aa-3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators of human α7 nAChR expressed in Xenopus ooctyesExpand
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Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents.
A natural monoterpene alkaloid incarvillateine isolated from the plant Incarvillea sinensis is known to relieve inflammatory and neuropathic pain. However, the molecular target for the action ofExpand
Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs.
Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human α7 nAChRExpand