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- Publications
- Influence
Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels.
- L. Shi, Xiling Bian, +5 authors J. Xie
- Chemistry, Medicine
- Nature communications
- 5 February 2013
The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for… Expand
Honokiol protects brain against ischemia–reperfusion injury in rats through disrupting PSD95–nNOS interaction
- Zhenyu Hu, Xiling Bian, X. Liu, Y. Zhu, Y. Wang
- Medicine
- Brain Research
- 23 January 2013
Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe the… Expand
Auxiliary KChIP4a Suppresses A-type K+ Current through Endoplasmic Reticulum (ER) Retention and Promoting Closed-state Inactivation of Kv4 Channels*
- Y. Tang, P. Liang, +4 authors K. Wang
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 10 April 2013
Background: Compared with other auxiliary KChIPs that enhance Kv4 current, KChIP4a inhibits Kv4 function. Results: We identified an ER retention motif and an adjacent VKL motif within the KChIP4a N… Expand
Physiological and morphological characterization of GABAergic neurons in the medial amygdala
- Xiling Bian
- Biology, Medicine
- Brain Research
- 6 May 2013
GABAergic neurons in the medial amygdala (MeA) have been indicated in information processing in reproductive behavior and fear/anxiety. However, basic knowledge of their physiological and… Expand
Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice
- Yeping Bi, H. Chen, J. Su, X. Cao, Xiling Bian, K. Wang
- Chemistry, Medicine
- Molecular pain
- 1 January 2011
BackgroundDysfunction of brain-gut interaction is thought to underlie visceral hypersensitivity which causes unexplained abdominal pain syndromes. However, the mechanism by which alteration of brain… Expand
Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice.
- Yuanheng Li, Lilan Sun, +11 authors Qi Sun
- Chemistry, Medicine
- Journal of medicinal chemistry
- 10 January 2019
A series of novel thiazolo[4,5- d]pyrimidin-7(6 H)-ones (3aa-3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators of human α7 nAChR expressed in Xenopus ooctyes… Expand
Erratum to: Elevated Expression of Acid-Sensing Ion Channel 3 Inhibits Epilepsy via Activation of Interneurons
- Qingqing Cao, W. Wang, +7 authors X. Wang
- Chemistry, Medicine
- Molecular Neurobiology
- 2015
Targeting voltage-gated Kv7/KCNQ/M-channel for therapeutic potential of neuropsychiatric disorders
- Xiling Bian, Kewei Wang
- Chemistry
- 30 January 2014
Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents.
- Xiling Bian, Y. Zhang, +7 authors K. Wang
- Chemistry, Medicine
- European journal of pharmacology
- 5 September 2019
A natural monoterpene alkaloid incarvillateine isolated from the plant Incarvillea sinensis is known to relieve inflammatory and neuropathic pain. However, the molecular target for the action of… Expand
Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs.
- Xiaoxin Li, Wenjun Xie, +4 authors Qi Sun
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 August 2019
Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human α7 nAChR… Expand