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Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila
These results provide a striking illustration of how the host immune response to a virulent pathogen can also be shaped by pathogen-encoded activities, such as inhibition of host protein synthesis.
Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response
This work demonstrates that a protein, called SidI, is a substrate of the Dot/Icm type IV protein transporter that targets the host protein translation process and indicates that inhibition of host protein synthesis by specific effectors contributes to the induction of stress response in L. pneumophila‐infected cells.
Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector
This report describes the identification and characterization of a Legionella protein termed SidK that specifically targets host v-ATPase, the multi-subunit machinery primarily responsible for organelle acidification in eukaryotic cells, and shows that a domain located in the N-terminal portion of SidK is responsible for its interactions with VatA.
Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family
SidF, one substrate of the Dot/Icm transporter, is involved in the inhibition of infected cells from undergoing apoptosis to allow maximal bacterial multiplication and constitutes a mechanism for L. pneumophila to protect host cells from apoptosis.
Taibaiella smilacinae gen. nov., sp. nov., an endophytic member of the family Chitinophagaceae isolated from the stem of Smilacina japonica, and emended description of Flavihumibacter petaseus.
Based on the phenotypic, phylogenetic and genotypic data, strain PTJT-5(T) is considered to represent a novel species of a new genus in the family Chitinophagaceae, for which the name Taibaiella smilacinae gen. nov. is proposed.
A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition
Links between type VI secretion, cell–cell signalling and classic siderophore receptors for iron acquisition in P. aeruginosa are revealed and are revealed to be synergistically with known iron acquisition systems.
Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity
The results assigned an unconventional role to T6SSs, which will lay the foundation for studying novel mechanisms of metal ion uptake by bacteria and the role of this process in their resistance to host immunity and survival in harmful environments.
Manganese scavenging and oxidative stress response mediated by type VI secretion system in Burkholderia thailandensis
The contact-independent functions of T6 SS for metal acquisition and bacteria–bacteria competition, reported here, suggest that T6SS may have been retrofitted by some bacteria to gain additional adaptive functions during evolution and provide a perspective for understanding the mechanisms of metal ion uptake and the roles of T 6SS in bacteria– bacteria competition.
The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore
The Pseudomonas quinolone signal (PQS) has been studied primarily in the context of its role as a quorum-sensing signaling molecule. Recent data suggest, however, that this molecule may also function
The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition.
It is found that HmuR is a redox-regulated dual-functional transporter that transports heme iron under normal conditions but zinc upon sensing extracellular oxidative stress, triggered by formation of an intramolecular disulfide bond.