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This paper presents methods and experimental results for phonetic classification using 39 phone classes and the NIST recommended training and test sets for NTIMIT and TIMIT. Spectral/temporal features which represent the smoothed trajectory of FFT derived speech spectra over 300 ms intervals are used for the analysis. Classification tests are made with both(More)
Tanshen, the rhizome of Salvia miltiorrhiza Bunge, has been used in Chinese traditional medicine (TCM) for multiple therapeutic remedies. The major constituents of Tanshen include water-soluble phenolic acids and lipophilic tanshinones. Phenolic acids possess antioxidant and anticoagulant activities, whereas tanshinones show antibacterial, antioxidant, and(More)
In this paper we present an approach for efficiently computing a compact temporal/spectral feature set for representing a segment of speech, with effective resolution depending on both frequency and time position within the segment. The goal is to mimic the resolution properties of the human auditory system, but using a computationally efficient FFT-based(More)
In our previous study, neo-tanshinlactone (1) showed potent and selective anti-breast cancer activity. To explore the SAR of 1, nine analogues (15-18, 24-28) were designed and synthesized. Together with 1 and tamoxifen (TAM), all newly synthesized compounds and some intermediates were evaluated for in vitro anticancer activity against several human tumor(More)
A series of acid-stable carboxamide derivatives of 2-guanidinoimidazolidinedione (5a-c and 6a-c) were prepared as potential malaria prophylactic and radical cure agents. The new compounds showed moderate to good causal prophylactic activity in mice infected with Plasmodium yoelii sporozoites. Three compounds were further tested for causal prophylactic(More)
The tanshinone natural products possess a variety of pharmacological properties including anti-bacterial, anti-inflammatory, anti-oxidant, and anti-neoplastic activity. The molecular basis of these effects, however, remains largely unknown. In the present study, we explored the direct effect of tanshinones on the enzyme telomerase. Telomerase is(More)
Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-,(More)
A shared space should be cooperatively maintained by all users. However, due to social loafing, often nobody maintains it and its condition worsens. We propose exudation of a shared space. Part of a shared space is exuded into personal workspaces so that office workers are forced to subjectively experience the atmosphere of the shared space, even while they(More)
A series of 2-guanidino-4-oxoimidazoline (deoxo-IZ) derivatives was prepared and showed potent antimalarial activities in rodent and Rhesus models. Compound 8e, the most potent analogues of this series, is the first non-8-aminoqinoline antimalarial that demonstrated radical curative activity in non-human primate by oral route and showed causal prophylactic(More)