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  • Xifu Liu, Xinhua Gu, +10 authors Mingdong Zhou
  • Medicine
  • Journal of the American College of Cardiology
  • 2006 (First Published: 1 October 2006)
  • OBJECTIVES We evaluated the therapeutic potential of a recombinant 61-residue neuregulin-1 (beta2a isoform) receptor-active peptide (rhNRG-1) in multiple animal models of heart disease. BACKGROUNDContinue Reading
  • Run-lin Gao, Jian Zhang, +8 authors Mingdong Zhou
  • Medicine
  • Journal of the American College of Cardiology
  • 2010 (First Published: 1 May 2010)
  • OBJECTIVES The purpose of this study was to assess the safety and efficacy of recombinant human neuregulin-1 (rhNRG-1) in chronic heart failure (CHF) patients. BACKGROUND Neuregulin-1 playsContinue Reading
  • Andrew Jabbour, Christopher S Hayward, +9 authors Peter S Macdonald
  • Medicine
  • European journal of heart failure
  • 2011
  • AIMS Neuregulin-1 (NRG-1) plays a critical role in the adaptation of the heart to injury, inhibiting apoptosis and inducing cardiomyocyte proliferation. We have shown previously that rhNRG-1 improvesContinue Reading