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In this study, primary cultured cerebral cortical neurons of Sprague-Dawley neonatal rats were treated with 0.25, 0.5, and 1.0 μM calmodulin-dependent protein kinase II inhibitor KN-93 after 50 μM N-methyl-D-aspartic acid-induced injury. Results showed that, compared with N-methyl-Daspartic acid-induced injury neurons, the activity of cells markedly(More)
The cerebellum has traditionally been looked upon as a brain area primarily involved in motor behavior. The last decade has however heralded the cerebellum as a brain region of renewed interest for neuropsychiatric disorders. The relationship between cerebellum and neuropsychiatric disorders are increasingly understood. Recent data suggests that cerebellar(More)
Accumulation of amyloid β-peptide (Aβ) in the brain of Alzheimer disease (AD) patients is believed to be the main pathological feature of the disease. Meanwhile, miR-98-5p dysregulation was found in AD. However, whether miR-98-5p is involved in the accumulation of Aβ in AD, the underlying molecule mechanism remains unclear. In the present study, we(More)
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